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  4. Human Thyroid Stimulating Hormone,TSH ELISA Kit

Human Thyroid Stimulating Hormone,TSH ELISA Kit

  • 中文名稱(chēng)：
    人促甲狀腺素(TSH)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E05114h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 促銷(xiāo)：
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人促甲狀腺素(TSH)酶聯(lián)免疫試劑盒（CSB-E05114h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿樣本中的TSH含量。TSH即促甲狀腺激素，是腺垂體分泌的促進(jìn)甲狀腺生長(zhǎng)和機(jī)能的激素。其在調(diào)節(jié)甲狀腺功能中起關(guān)鍵作用。研究圍繞其與甲狀腺激素的反饋調(diào)節(jié)機(jī)制展開(kāi)，探索其相關(guān)信號(hào)通路，以深入了解甲狀腺疾病發(fā)病機(jī)制及為治療提供新思路。試劑盒檢測(cè)范圍為0.3 uIU/mL-12 uIU/mL，靈敏度為0.15 μIU/mL。該產(chǎn)品適用于甲狀腺功能相關(guān)動(dòng)物模型研究、激素替代療法藥效評(píng)估、環(huán)境內(nèi)分泌干擾物篩查等科研領(lǐng)域，也可用于體外培養(yǎng)細(xì)胞或組織樣本中TSH分泌水平的動(dòng)態(tài)監(jiān)測(cè)，為代謝調(diào)控、生殖健康等基礎(chǔ)醫(yī)學(xué)研究提供可靠數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    TSHBThyrotropin subunit beta ELISA kit; Thyroid-stimulating hormone subunit beta ELISA kit; TSH-B ELISA kit; TSH-beta ELISA kit; Thyrotropin beta chain ELISA kit; Thyrotropin alfa ELISA kit
  • 縮寫(xiě)：
    TSH
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類(lèi)型：
    serum, plasma
  • 檢測(cè)范圍：
    0.3 uIU/mL-12 uIU/mL
  • 靈敏度：
    0.15 μIU/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<15%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線(xiàn)性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TSH in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:1 Average % 96  
    Range % 92-104  
    1:2 Average % 94  
    Range % 91-98  
    1:4 Average % 102  
    Range % 98-106  
    1:8 Average % 88  
    Range % 82-94  
  • 回收率：
    The recovery of human TSHspiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 94 90-98  
    EDTA plasma (n=4) 103 98-107  
                 
                 
  • 標(biāo)準(zhǔn)曲線(xiàn)：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    μIU/ml OD1 OD2 Average    
    12 2.219 2.354 2.287    
    6 1.215 1.254 1.235    
    3 0.648 0.664 0.656    
    1.5 0.361 0.354 0.358    
    0.6 0.155 0.158 0.157    
    0.3 0.078 0.079 0.079    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    TSH是促甲狀腺激素，它調(diào)節(jié)了甲狀腺素的合成和釋放。最新的研究表明，TSH除了在甲狀腺疾病中的重要作用外，還可能參與調(diào)節(jié)骨骼和代謝健康，影響肥胖和糖尿病的發(fā)生和發(fā)展。
  • 功能：
    Indispensable for the control of thyroid structure and metabolism.
  • 基因功能參考文獻(xiàn)：
    1. Serum macro TSH level is associated with sleep quality in patients with cardiovascular risks. PMID: 28287185
    2. present the cases of two siblings with a novel mutation of TSHB. One of them was c.40A>G (rs10776792) which is a very common variation that is also seen in healthy individuals, the other was c.94G>A at codon 32 of exon 2 which resulted in a change from glutamic acid to lysine (p.E32K PMID: 28515030
    3. The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower. PMID: 26898119
    4. results provide novel evidence of TSHB as a paracrine factor that is modulated in parallel with cholesterol metabolism in human adipose tissue PMID: 28646016
    5. In hyperthyroidism, bone marrow resident macrophages have the potential to exert enhanced osteoprotective effects by oversecreting a TSH-beta splice variant. PMID: 27300765
    6. In the context of metabolic syndrome, a higher TSH within the euthyroid range confers an increased leptin/adiponectin ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction. PMID: 28077136
    7. the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis, is reported. PMID: 27351808
    8. Data suggest that the subtle thyroid-stimulating hormone (TSH) reduction could possibly reflect minor hypothalamic-pituitary damage. PMID: 26432979
    9. analysis of a single nucleotide substitution in TSHbeta related to clinical euthyroidism [family case report] PMID: 25950606
    10. Findings defined the immune-derived functional TSHb splice variant that resided in the thyroid of patients with Hashimoto's thyroiditis (HT), which exerted the unique effects on the pathogenesis of the disease. PMID: 26170068
    11. Serum TSH was associated with pulse wave velocity on population level when adjusted with age and sex. PMID: 25185682
    12. Higher TSH levels are associated with less favorable lipid levels in children PMID: 25781359
    13. In cases with isolated central congenital hypothyroidism and undetectably low TSH serum concentrations, a TSHbeta gene deletion should be considered PMID: 25012771
    14. Epistasis between single nucleotide polymorphisms within the TSHB and ADAMTS16 genes may increase the risk of premature ovarian failure in Korean women. PMID: 24366283
    15. High Thyroid Stimulating Hormone levels are associated with papillary thyroid carcinoma. PMID: 24595799
    16. bTSH Induces IL-6 Protein and mRNA in Orbital Fibroblasts and Fibrocytes PMID: 24086448
    17. The use of these age-specific reference intervals for TSH, especially in those over 70 years old, would result in the reclassification of many TSH results from "abnormal" to "normal" and avoid unnecessary treatment. PMID: 23345094
    18. In Hashimoto's thyroiditis the hTSHbeta splice variant exists in human serum and dimerises with TSHalpha. PMID: 22752807
    19. Data suggest that a progressive increase in TSH are predictive factors for thyroid failure in Hashimoto's thyroiditis (HT) patients. PMID: 21981142
    20. Data suggest that likelihood of papillary thyroid carcinoma is reduced when serum TSH is lower, as in thyroid autonomy, and increased when serum TSH is higher, as in thyroid autoimmunity. [Meta-Analysis; REVIEW] PMID: 22278420
    21. Studies indicate that immune system-derived TSH, in particular, a splice variant of TSHbeta that is preferentially made by cells of the immune system, is produced by a subset of hematopoietic cells that traffic to the thyroid. PMID: 20826543
    22. Results suggest that a serum TSH concentration at the lower end of the reference range may be associated with low BMD in men. PMID: 20455884
    23. Novel mutations of the TSH-beta subunit gene underlying congenital central hypothyroidism undetectable in neonatal TSH screening. PMID: 20534762
    24. we describe two new sibships with isolated congenital central hypothyroidism due to two different homozygous TSHbeta gene mutations (c.Q49X and c.C105fs114X). PMID: 20553196
    25. TSHbeta variants C105Vfs114X and Q49X are the most frequent cause of this severe disorder in Europe, now for the first time observed in compound heterozygous state. PMID: 15297803
    26. Data suggest that the expression of Pit-1 in cells of the alpha SU-based gonadotropin cell lineage might also lead to the expression of growth hormone, prolactin, and thyroid-stimulating hormone beta subunit. PMID: 16133148
    27. N-CoR and TRbeta cooperate in the regulation of the TSHbeta gene and this ligand-dependent repression is mediated by the LXXLL motif in N-CoR PMID: 16216492
    28. Serum TSH is frequently suppressed after treatment with antithyroid drugs. PMID: 17954417
    29. In a cohort of pregnant women without overt thyroid dysfunction, the risk of child loss increased with higher levels of maternal TSH. PMID: 19273570
    30. Human pituitary, thyroid, and mononuclear leukocytes express a TSHbeta isoform that is analogous to the mouse TSHbeta isoform, consisting of a 27 nucleotide portion of intron 2 and all of exon 3, coding for 71.2% of the native human TSHbeta polypeptide. PMID: 19364510

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Glycoprotein hormones subunit beta family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12372

    OMIM: 188540

    KEGG: hsa:7252

    STRING: 9606.ENSP00000256592

    UniGene: Hs.406687