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LAG3

LAG-3是一種具有免疫抑制功能的跨膜蛋白,其結(jié)構(gòu)由胞外區(qū)的四個(gè)免疫球蛋白超家族結(jié)構(gòu)域、跨膜區(qū)和胞內(nèi)區(qū)的絲氨酸磷酸化位點(diǎn)等關(guān)鍵元件組成。功能上,LAG-3主要通過(guò)與配體如MHC II、半乳糖凝集素-3等的相互作用,抑制T細(xì)胞的激活和細(xì)胞因子分泌,從而維持免疫穩(wěn)態(tài)。在信號(hào)通路方面,LAG-3與其配體結(jié)合后,通過(guò)胞內(nèi)結(jié)構(gòu)域與下游信號(hào)分子的相互作用,調(diào)節(jié)T細(xì)胞的活化狀態(tài)。在腫瘤治療中,LAG-3作為重要靶點(diǎn),通過(guò)阻斷或抑制LAG-3可增強(qiáng)T細(xì)胞對(duì)腫瘤的殺傷作用。因此,深入研究LAG-3的結(jié)構(gòu)、功能和信號(hào)通路,對(duì)于開(kāi)發(fā)新的免疫療法具有重要意義。


熱銷(xiāo)產(chǎn)品

Recombinant Human Lymphocyte activation gene 3 protein (LAG3), partial (Active) (CSB-MP012719HU3)

驗(yàn)證數(shù)據(jù)

CSB-MP012719HU3

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012719HU3

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human LAG3 at 2 μg/ml can bind Anti-LAG3 recombinant antibody(CSB-RA012719MA1HU). The EC50 is 2.306-2.731 ng/mL.

LAG3 Recombinant Monoclonal Antibody (CSB-RA012719MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA012719MA1HU

IHC image of CSB-RA012719MA1HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA012719MA1HU

The Binding Activity of Human LAG3 with Anti-LAG3 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LAG3(CSB-MP012719HU3) at 2 μg/mL can bind Anti-LAG3 recombinant antibody. The EC50 is 2.306-2.731 ng/mL.

Human Lymphocyte activation gene 3 protein(LAG3) ELISA kit (CSB-EL012719HU)

驗(yàn)證數(shù)據(jù)

CSB-EL012719HU 標(biāo)準(zhǔn)曲線(xiàn)

貨號(hào):CSB-EL012719HU

規(guī)格:96T/48T

靈敏度:0.039 ng/mL

檢測(cè)范圍:0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

LAG3 Antibodies

LAG3 for Homo sapiens (Human)

LAG3 Proteins

LAG3 Proteins for Homo sapiens (Human)

LAG3 ELISA Kit

LAG3 ELISA Kit for Homo sapiens (Human)



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