Recombinant Human Epigen protein (EPGN), partial (Active)

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產品詳情

純度：

>98% as determined by SDS-PAGE.
內毒素：

Less than 1.0 EU/μg as determined by LAL method.
生物活性：

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 300 ng/ml, corresponding to a specific activity of >3.3x10³ IU/mg.
基因名：

EPGN
Uniprot No.：

Q6UW88
別名：

ALGV3072; EPG; EPGN; EPGN_HUMAN; Epigen; Epigen precursor; Epithelial mitogen; PRO9904
種屬：

Homo sapiens (Human)
蛋白長度：

Partial of Isoform 2
來源：

E.Coli
分子量：

7.9 kDa
表達區域：

24-95aa
氨基酸序列

AVTVTPPITA QQADNIEGPI ALKFSHLCLE DHNSYCINGA CAFHHELEKA ICRCFTGYTG ERCEHLTLTS YA
蛋白標簽：

Tag-Free
產品提供形式：

Liquid or Lyophilized powder
緩沖液：

0.2 μm filtered PBS, pH 7.4 ,lyophilized
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

5-10 business days
Datasheet & COA：

Please contact us to get it.

功能：

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.
基因功能參考文獻：
1. Study shows how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. Results reveal how responses to different EGFR ligands are defined by receptor dimerization strength and signaling dynamics. These findings have broad implications for understanding receptor tyrosine kinase (RTK) signaling specificity. PMID: 28988771
2. cloning of a related gene in mouse PMID: 112783
3. EPG is an EGF-like growth factor and a low affinity ligand PMID: 15611079
亞細胞定位：

[Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.
數據庫鏈接：

HGNC: 17470

KEGG: hsa:255324

UniGene: Hs.401237