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  4. Recombinant Mouse Interleukin-3 protein (Il3), partial

Recombinant Mouse Interleukin-3 protein (Il3), partial

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  • 中文名稱：
    小鼠Il3重組蛋白
  • 品名簡稱：
    Recombinant Mouse Il3 protein, partial (Active)
  • 貨號：
    CSB-AP003291MO
  • 說明書：
  • 規(guī)格：
    ￥2124
  • 圖片：
  • 其他：

產(chǎn)品詳情

  • 純度：
    >98% as determined by SDS-PAGE.
  • 內(nèi)毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is less than 0.05 ng/ml, corresponding to a specific activity of >2x107 IU/mg.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Il3; Csfmu; Il-3; Interleukin-3; IL-3; Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 來源：
    E.Coli
  • 分子量：
    14.8 kDa
  • 表達區(qū)域：
    33-166aa
  • 氨基酸序列
    DTHRLTRTLN CSSIVKEIIG KLPEPELKTD DEGPSLRNKS FRRVNLSKFV ESQGEVDPED RYVIKSNLQK LNCCLPTSAN DSALPGVFIR DLDDFRKKLR FYMVHLNDLE TVLTSRPPQP ASGSVSPNRG TVEC
  • 蛋白標(biāo)簽：
    Tag-Free
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
  • 緩沖液：
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.; This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
  • 基因功能參考文獻：
    1. Jak1-deficient hematopoietic stem cells exhibit increased quiescence, an inability to enter the cell cycle in response to hematopoietic stress, and a marked reduction in cytokine sensing, including in response to type I interferons and IL-3. PMID: 28965767
    2. findings indicate that STAT5 contributes to the remarkable IL-3-mediated inhibition of RANKL-induced osteoclastogenesis by activating Id genes and their associated pathways. PMID: 27485735
    3. c-Kit(+) Adipose tissue-derived mesenchymal stem cells (ASCs)may promote breast cancer growth and angiogenesis by a synergistic effect of c-Kit and IL-3. Our findings suggest that c-Kit(+) subpopulations of ASCs should be eliminated in fat grafts for breast reconstruction of cancer patients following mastectomy. PMID: 28573141
    4. These impaired macrophage functions in leukemic mice were significantly corrected by IL-3 and GM-CSF treatment indicating the therapeutic benefit of these two cytokines in leukemia. PMID: 28039843
    5. IL-3 signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis. PMID: 26589916
    6. Thus, IL-3 plays an important role in the pathogenesis of SLE and the progression of lupus nephritis. PMID: 26131743
    7. Cytoplasmic granule containing HERMES, NonO, PSF, and G3BP1 is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation. PMID: 25651939
    8. Stem cell factor (SCF), but not interleukin-3 (IL-3), is a major effector of HSC maturation during embryonic day E9-E10. PMID: 25241746
    9. study reports IL3 potentiates inflammation in sepsis; in model of abdominal sepsis, findings show innate response activator B cells produce IL3, which induces myelopoiesis of monocytes and neutrophils and fuels cytokine storm; IL3 deficiency protects against sepsis PMID: 25766237
    10. Altered expression of CD30L and IL-3 may be potential biomarkers for hepatotoxicity induced by D. bulbifera. PMID: 24647110
    11. This study is the first to link beta-catenin activation to IL-3 and suggests that targeting IL-3 signaling may be an effective approach for the inhibition of beta-catenin activity in some patients with AML. PMID: 24598054
    12. IL-3 plays a critical role in suppressing protective immunity to P. berghei NK65 infection. PMID: 24379292
    13. IL-3 promotes Stat5 activation in osteoclasts. PMID: 24367002
    14. these findings not only provide a better understanding of the role of IL-3 in osteoclastogenesis but may also facilitate future studies to delineate the role of IL-3 in the pathogenesis of bone diseases. PMID: 24103757
    15. At day 10, CIP treatment not only significantly reduced pro-inflammatory cytokine and chemokine concentrations, including interleukin-6 (IL-6) and KC, but it also enhanced IL-3 production compared to vehicle-treated controls. PMID: 23520506
    16. IL-3 upregulates Trib3 mRNA expression in bone-marrow-derived mast cells. During prolonged IL-3 starvation, cell death is accelerated in Trib3-null cultures. PMID: 23261831
    17. confirm for the first time that IL-3 and IL-4 are critical for IL-33 intracrine in murine cells of various types, indicating that IL-3 and IL-4 may play an important role in the constitutive expression of IL-33 in vivo PMID: 22370606
    18. p53(-/-) cells have a deregulated intracellular signaling environment and display a more rapid and sustained response to IL-3. This was accompanied by an increase in active ERK1/2 and a dependence on an intact MAP kinase signaling pathway PMID: 22348085
    19. Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation PMID: 22068549
    20. these findings suggest CNSa is a distal enhancer of the IL-3/GM-CSF gene cluster that binds BRG1 and NF-kappaB PMID: 21831442
    21. IL-3 markedly amplifies primitive erythroid and macrophage precursors in E7.5 embryos and has a regulatory role with regard to both number and capacity of the dual-potential hemangioblast. PMID: 20007140
    22. Inhibition of IL-3 signaling and knockdown of Xbp1-induced apoptosis in hematopoietic cells. PMID: 21368889
    23. Data indicate a role for PLCgamma2 and Ca(2+) signaling through the modulation of MEK/ERK in IL3/GM-csf stimulated mouse hematopoietic stem/progenitor cells. PMID: 21506110
    24. structural studies of soluble, recombinant IL3 fragment (33-156): four-helical bundle fold; conformation typical of short-chain cytokines; core of highly conserved hydrophobic residues; pronounced conformational heterogeneity PMID: 21329364
    25. Complex interactions in EML cell stimulation by stem cell factor and IL-3. PMID: 21383156
    26. Recombinant murine IL-3 plays an important role in modulating regulatory T (Treg) cell development in both in vitro and in vivo conditions and significantly reduces the severity of collagen-induced arthritis. PMID: 21242512
    27. Studies indicate that BMP and IL-3 signaling pathways are critical for the growth and potential of embryonic HSCs. PMID: 20711995
    28. SHP-1 positively regulates IL-3-dependent mast cell proliferation and apoptosis by inhibiting ERK activity through its phosphatase activity. PMID: 21044800
    29. IL-3 irreversibly inhibits RANK expression that results in inhibition of important signaling molecules induced by RANKL during osteoclastogenesis. PMID: 20691668
    30. the domain 1 D-E loop disulfide of hbetac and beta(IL-3) in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling PMID: 20516062
    31. Two different modes of beta c binding are utilized in the presence of the hIL-3R alpha isoforms. PMID: 20472554
    32. The IL-3/IL-3 receptor system is absolutely required to recruit circulating basophils into the draining lymph nodes following helminth infection. PMID: 20038645
    33. IL-3 and oncogenic Abl regulate the myeloblast transcriptome by altering mRNA stability PMID: 19829692
    34. p53 protein is activated after IL-3 deprivation by loss of MDM2. Activated p53 transcriptionally up-regulates Puma, which initiates apoptosis. PMID: 19965665
    35. Role of pRB-family/E2F complex in the inhibition of IL-3-dependent lymphoid cell proliferation. PMID: 11886176
    36. relevance to peripheral myeloid recruitment PMID: 12115609
    37. IL-3-driven survival and proliferation is negatively regulated, potentially via tyrosine phosphorylation of Aic2A and STAT5 PMID: 12220225
    38. IL3 is required for mitochondrial respiratory control PMID: 12228733
    39. evidence that IL-3 production is a rapid, sustained, and biologically relevant consequence of BCR-ABL expression in primitive hematopoietic cells with multilineage leukemogenic activity PMID: 12393460
    40. IL-3 induces activation of the PI-3 kinase, MAP kinase, & Jak/Stat pathways. Jak2 activation is the critical "proximal" mediator of the IL-3-induced enhancement of RAR activity. PMID: 12393611
    41. IL-3 inhibits osteoclastogenesis in whole bone marrow cells by directly acting on osteoclast precursors, irreversibly blocking receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation by diverting the cells to macrophage lineage. PMID: 12816992
    42. The time courses for activation of phosphatidylinositol 3-kinase and its downstream target, protein kinase B, by IL-3 were consistent with a role in IL-3-induced transporter translocation and enhanced glucose uptake. PMID: 12869574
    43. Interleukin-3 and flt3 ligand induce expression of antiapoptotic Bcl-2 family genes. PMID: 12960281
    44. Interleukin-3 binding to the murine betaIL-3 receptor involves functional epitopes formed by domains 1 and 4 of different protein chains PMID: 15060062
    45. IL-3 plays a crucial role for IgE(-Ag)-induced mast cell survival, functioning in an autocrine manner by inducing the Bcl-xL/Bcl-2 via signal transducer and activator of transduction 5 PMID: 15542585
    46. IL-3 induces inhibitor of DNA-binding protein 1 (Id1) expression in multipotential erythroid-myeloid-lymphoid cells during myeloid, but not B cell or erythroid cell differentiation. PMID: 15905544
    47. Results describe the effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling. PMID: 16371368
    48. The importance of IL-3-induced TNF secretion was demonstrated by the failure of TNF-deficient bone marrow cells to survive for >3 wk when cultured in IL-3 and SCF, a defect that was reversed by the addition of soluble TNF PMID: 16455967
    49. Inhibition of the PI3 kinase pathway promoted apoptosis in the presence or absence of IL-3. PMID: 16705087
    50. in mice with markedly impaired SCF/c-Kit signaling, IL-3 contributed significantly to the increased numbers of eosinophils that were observed during Strongyloides venezuelensis infection, but not during infection with Nippostrongylus brasiliensis PMID: 16894356

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    IL-3 family
  • 組織特異性：
    Activated T-cells, mast cells, natural killer cells.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:16187

    STRING: 10090.ENSMUSP00000019058

    UniGene: Mm.983