EXOSC1 Monoclonal Antibody
-
中文名稱:EXOSC1 Monoclonal Antibody
-
貨號:CSB-MA286847
-
規格:¥1320
-
圖片:
-
Immunocytochemical staining of HepG2 cells with Exosome component 1 antibody. Nuclei were stained blue with DAPI; Exosome component 1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain:. Scale bar, 20 μm.
-
Western blotting analysis using exosome component 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with exosome component 1 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
-
-
其他:
產品詳情
-
產品名稱:Mouse anti-Homo sapiens (Human) EXOSC1 Monoclonal antibody
-
Uniprot No.:
-
基因名:EXOSC1
-
別名:EXOSC1; Exosome Component 1; CSL4; CGI-108; Csl4p; Ski4p; SKI4; P13; Exosome Complex Component CSL4; HCsl4p; Homolog Of Yeast Exosomal Core Protein CSL4; CSL4 Exosomal Core Protein Homolog (Yeast); 3'-5' Exoribonuclease CSL4 Homolog; Exosomal Core Protein CSL4; PCH1F
-
宿主:Mouse
-
反應種屬:Human, Mouse, Rat
-
免疫原:Recombinant Human EXOSC1 protein
-
免疫原種屬:Homo sapiens (Human)
-
標記方式:Non-conjugated
-
克隆類型:Monoclonal
-
抗體亞型:Mouse IgG1
-
純化方式:Affinity-chromatography
-
克隆號:13D5
-
濃度:It differs from different batches. Please contact us to confirm it.
-
保存緩沖液:PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
-
產品提供形式:Liquid
-
應用范圍:ELISA, WB, ICC
-
推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2500 ICC 1:100-1:1000 -
Protocols:
-
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相關產品
靶點詳情
-
功能:Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
-
基因功能參考文獻:
- The combined p16- and p53-expression status in cervical metastases of CUP may represent a simple method for risk stratification. Further validation of these biomarkers in large prospective trials is essential to design rational trials for CUP treatment optimization. PMID: 28144684
- Human exosome hCsl4p participates in RNA degradation. PMID: 22068837
- association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p PMID: 11812149
-
亞細胞定位:Nucleus, nucleolus. Nucleus. Cytoplasm.
-
蛋白家族:CSL4 family
-
數據庫鏈接:
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
-
-
-
-
-















