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  4. FBXO11 Monoclonal Antibody

FBXO11 Monoclonal Antibody

  • 中文名稱：
    FBXO11 Monoclonal Antibody
  • 貨號：
    CSB-MA978749
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of FBXO11 expression in HeLa cells using FBXO11 antibody. Green, isotype control; red, FBXO11.
    • Western blotting analysis using FBXO11 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with FBXO11 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) FBXO11 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    FBXO11
  • 別名：
    FBXO11; F-Box Protein 11; FBX11; F-Box Only Protein 11; UBR6; Ubiquitin Protein Ligase E3 Component N-Recognin 6; Protein Arginine N-Methyltransferase 9; Vitiligo-Associated Protein 1; PRMT9; VIT1; Vitiligo-Associated Protein VIT-1; UG063H01; IDDFBA; VIT-1
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human FBXO11 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    23B7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:2500-1:5000
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
  • 基因功能參考文獻：
    1. High expression of FBXO11 predicted a poor survival of hepatocellular carcinoma patients. PMID: 29518611
    2. Understanding of the functions of FBXO11. PMID: 29278851
    3. FBXO11 is a direct target of miR-621 in breast cancer cells. PMID: 25867061
    4. UBR3/6 regulate cardiomyocyte Nav 1.5 channel protein levels via the ubiquitin-proteasome pathway. PMID: 26059563
    5. siRNA-mediated knockdown of FBXO11 facilitated HIF-1alpha expression in various cancer cells and HIF-1alpha-driven gene expressions, but the FBXO10 knockdown did not. PMID: 26187670
    6. Our results identify FBXO11 as a novel miR-21 target gene, and demonstrate that the oncogenic miRNA miR-21 decreases the expression of FBXO11, which normally acts as a tumor suppressor, and thereby promotes tumorigenesis. PMID: 25589783
    7. The PKD1-FBXO11-SNAIL axis is a mechanism of posttranslational regulation of epithelial-mesenchymal transition and cancer metastasis. PMID: 25203322
    8. TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2. PMID: 23892434
    9. The functional interaction between FBXO11 and CDT2 is evolutionary conserved from worms to humans and plays an important role in regulating the timing of cell-cycle exit. PMID: 23478441
    10. Migration of epithelial cells is stimulated by CRL1(FBXO11)-mediated downregulation of Cdt2 and the consequent stabilization of Set8. PMID: 23478445
    11. A molecular mechanism controlling BCL6 stability--mutations and deletions in FBXO11 contribute to lymphomagenesis through BCL6 stabilization PMID: 22113614
    12. these data provide strong evidence for FBXO11 as a susceptibility gene for severe OM. PMID: 21293382
    13. Results support the notion that FBXO11 plays an important role in regulating proliferation and apoptosis of melanocytes, and functional export of tyrosinase from ER in vitiligo melanocytes. PMID: 20514423
    14. FBXO11 has a lower expression in skin lesion tissues than in normal tissues from vitiligo patients. PMID: 20646433
    15. A type II protein arginine methyltransferase that forms asymmetric dimethylarginine modifications in proteins. PMID: 16487488
    16. The FBXO11 gene is the human homologue of the gene mutated in the novel deaf mouse mutant jeff (Jf), a single gene model of otitis media. FBXO11 gene for association with chronic otitis media with effusion. PMID: 16847180
    17. FBXO11 promotes the Neddylation (NEDD8) of p53 and inhibits its transcriptional activity PMID: 17098746

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  • 相關疾病：
    Defects in FBXO11 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL6, an oncoprotein that has a critical role in lymphomas.
  • 亞細胞定位：
    Nucleus. Chromosome.
  • 組織特異性：
    Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
  • 數據庫鏈接：

    HGNC: 13590

    OMIM: 607871

    KEGG: hsa:80204

    STRING: 9606.ENSP00000384823

    UniGene: Hs.352677