The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA067150(ACTR3B Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA067150(ACTR3B Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, Jurkat cells, Primary antibody: CSB-PA067150(ACTR3B Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.
基因功能參考文獻:
Thus, overexpression of Arp11 may suppress tumorigenicity in nude mice. PMID: 14651955
亞細胞定位:
Cytoplasm, cytoskeleton. Cell projection.
蛋白家族:
Actin family, ARP3 subfamily
組織特異性:
Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adeno