DTX4 Antibody, FITC conjugated

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DTX4 Polyclonal antibody
Uniprot No.：

Q9Y2E6
基因名：

DTX4
別名：

Deltex4 antibody; Dtx4 antibody; DTX4_HUMAN antibody; E3 ubiquitin-protein ligase DTX4 antibody; Protein deltex-4 antibody; RING finger protein 155 antibody; RNF155 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase DTX4 protein (167-432AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
基因功能參考文獻：
1. Notch is ligand activated and undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing PMID: 28611181
2. Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation. PMID: 22388039
亞細胞定位：

Cytoplasm.
蛋白家族：

Deltex family
數據庫鏈接：

HGNC: 29151

OMIM: 616110

KEGG: hsa:23220

STRING: 9606.ENSP00000227451

UniGene: Hs.523696