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PSMC2 Antibody

  • 中文名稱：
    PSMC2兔多克隆抗體
  • 貨號：
    CSB-PA018890GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PSMC2
  • 別名：
    26S protease complex antibody; 26S protease regulatory subunit 7 antibody; 26S proteasome AAA-ATPase subunit RPT1 antibody; mammalian suppressor of sgv-1 of yeast antibody; MSS1 antibody; Nbla10058 antibody; protease 26S subunit 7 antibody; Proteasome 19S S7 antibody; proteasome 26S ATPase subunit 2 antibody; Proteasome 26S subunit ATPase 2 antibody; Proteasome 26S subunit ATPase 2 antibody; Protein MSS1 antibody; PRS7_HUMAN antibody; PSMC2 antibody; putative protein product of Nbla10058 antibody; S7 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PSMC2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
  • 基因功能參考文獻：
    1. the finding of this study provided the new insight into the mechanism how PSMC2 contribute to osteosarcoma malignancy and further suggested PSMC2 might serve as an attractive potential therapeutic target drug target for osteosarcoma treatment. PMID: 27888613
    2. structural determinants for the binding of ubiquitin-like domains to 26s proteasome PMID: 12970176
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    AAA ATPase family
  • 數據庫鏈接：

    HGNC: 9548

    OMIM: 154365

    KEGG: hsa:5701

    STRING: 9606.ENSP00000292644

    UniGene: Hs.437366