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  4. Recombinant Mouse Dimethylaniline monooxygenase [N-oxide-forming] 5 (Fmo5)

Recombinant Mouse Dimethylaniline monooxygenase [N-oxide-forming] 5 (Fmo5)

  • 中文名稱：
    小鼠Fmo5重組蛋白
  • 貨號：
    008751MO
  • 規格：
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    Fmo5
  • 別名：
    Fmo5Dimethylaniline monooxygenase [N-oxide-forming] 5; EC 1.14.13.8; Dimethylaniline oxidase 5; Hepatic flavin-containing monooxygenase 5; FMO 5
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 應用說明：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 儲存條件：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.
  • 基因功能參考文獻：
    1. Fmo5(-)(/)(-) mice have metabolic characteristics similar to those of germ-free mice, indicating that FMO5 plays a role in sensing or responding to gut bacteria. In WT mice, FMO5 is present in the mucosal epithelium of the gastrointestinal tract where it is induced in response to a high-fat diet. PMID: 28646079
    2. The phenotype of a knockout mouse identifies FMO5 as a regulator of metabolic aging. PMID: 26049045
    3. The functional activity of Fmo5 was determined. PMID: 17721934
  • 亞細胞定位：
    Microsome membrane. Endoplasmic reticulum membrane.
  • 蛋白家族：
    FMO family
  • 組織特異性：
    Expressed in liver (at protein level). Expressed in the mucosal epithelium of the gastrointestinal tract.
  • 數據庫鏈接：