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  4. Recombinant Mouse Amyloid beta A4 precursor protein-binding family A member 2 (Apba2)

Recombinant Mouse Amyloid beta A4 precursor protein-binding family A member 2 (Apba2)

  • 中文名稱：
    Recombinant Mouse Amyloid beta A4 precursor protein-binding family A member 2(Apba2)
  • 貨號：
    001887MO
  • 規(guī)格：
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    Apba2
  • 別名：
    Apba2; X11lAmyloid-beta A4 precursor protein-binding family A member 2; Adapter protein X11beta; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Mint-2
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 應(yīng)用說明：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 儲存條件：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
  • 基因功能參考文獻(xiàn)：
    1. Results indicate that both X11 and X11L exert largely in brain neurons, but X11 may also function in peripheral tissues. PMID: 27268412
    2. Mints 1 and 2 perform redundant synaptic functions and have a role in regulation of gamma-aminobutyric acid release PMID: 12547917
    3. X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice PMID: 15347685
    4. APPPS1 mice are well suited for studying therapeutic strategies and the pathomechanism of amyloidosis by cross-breeding to other genetically engineered mouse models. PMID: 16906128
    5. X11L suppresses the amyloidogenic but not amyloidolytic processing of APP in regions of the brain such as the hippocampus, which express significant levels of X11L. PMID: 17032642
    6. shuttled between the cytoplasm and nucleus, the former more effectively than the latter; leptomycin B (LMB) induced substantial nuclear accumulation of EGFP-X11L PMID: 18201694
    7. X11s associate primarily with APP molecules that are outside of DRM, that the dissociation of APP-X11/X11L complexes leads to entry of APP into DRM, and that cleavage of uncomplexed APP by BACE within DRM PMID: 18845544
    8. This study suggested X11L is involved in the development of neuronal circuits that contribute to conflict resolution. PMID: 19420255

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  • 組織特異性：
    Specifically expressed in neurons, predominantly of the cerebellum, hippocampus, and spinal cord. Lesser extent in neurons of the cerebral cortex and anterior thalmic nuclei.
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