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  4. Recombinant Bovine cGMP-gated cation channel alpha-1 (CNGA1), partial

Recombinant Bovine cGMP-gated cation channel alpha-1 (CNGA1), partial

  • 中文名稱：
    Recombinant Bovine cGMP-gated cation channel alpha-1(CNGA1) ,partial
  • 貨號：
    005642BO1
  • 規格：
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CNGA1; CNCG; CNCG1; cGMP-gated cation channel alpha-1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
  • 免疫原種屬：
    Bos taurus (Bovine)
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 應用說明：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 儲存條件：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.
  • 基因功能參考文獻：
    1. These results suggest that restraining the A' helix to the plasma membrane potentiates CNGA1 channel opening. PMID: 26969165
    2. Conformation changes of CNGA1 associated with its gating function are reported. PMID: 25963832
    3. Data show that when Pro365 is replaced with a threonine in cyclic nucleotide gated channel alpha 1 (CNGA1), cesium Cs+ permeation is nearly abolished. PMID: 26100907
    4. Stabilizing the C-helix of intact CNGA1 channels by metal binding to a pair of histidines promoted channel opening. PMID: 23525108
    5. A ring of threonines in the inner vestibule of the pore of CNGA1 channels constitutes a binding site for permeating ions PMID: 22869010
    6. Three CNGA1 subunits and a single CNGB1 subunit form the rod cyclic nucleotide-gated ion channels. PMID: 21878911
    7. Existence of a strong coupling between the upper portion of the S6 helix provides a simple molecular mechanism for CNGA1 gating. PMID: 19289572
    8. The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry PMID: 12432397
    9. Data suggest that the native rod cyclic nucleotide-gated (CNG) channel is a tetramer composed of three A1 and one B1 subunit. PMID: 12467591
    10. Data show that the cyclic nucleotide-gated (CNG) channel contains three CNGA1 subunits and only one CNGB1 subunit. PMID: 12467592
    11. Structural models of the tetrameric cyclic nucleotide gated channel alpha 1 from bovine rod is presented. PMID: 15792804
    12. In CNGA1 channels, pore gating is involved in the rate-limiting reactions determining the activation time course in the sequence of events between cGMP binding and pore opening. PMID: 16473910
    13. These observations suggest that these effects are mediated by the formation of a disulfide bond (S-S) between F380C and the endogenous Cys-314 in the S5 segment. PMID: 16513780
    14. analyze in detail the molecular mechanisms underlying Cd2+ inhibition and longer cross-linkers in mutant CNGA1 channels PMID: 19132361
    15. detailed analysis of conformational changes of the S6 domain and C-linker during gating of CNGA1 channels PMID: 19488745

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA1 subfamily
  • 組織特異性：
    Expressed in the retina, in rod cells (at protein level).
  • 數據庫鏈接：

    KEGG: bta:281700

    STRING: 9913.ENSBTAP00000002853

    UniGene: Bt.53