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FNTA Recombinant Monoclonal Antibody

  • 中文名稱：
    FNTA Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA436461A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western blotting analysis using FNTA antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with FNTA antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    FNTA
  • 別名：
    FNTA; Farnesyltransferase, CAAX Box, Subunit Alpha; Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha; PGGT1A; PTAR2; FPTA; Protein Prenyltransferase Alpha Subunit Repeat Containing 2; Ras Proteins Prenyltransferase Subunit Alpha; Farnesyltransferase, CAAX Box, Alpha; GGTase-I-Alpha; FTase-Alpha; Type I Protein Geranyl-Geranyltransferase Alpha Subunit; Type I Protein Geranyl-Geranyltransferase Subunit Alpha; Farnesyl-Protein Transferase Alpha-Subunit; CAAX Farnesyltransferase Subunit Alpha; EC 2.5.1.58; EC 2.5.1.59
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human FNTA protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2G1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
  • 基因功能參考文獻：
    1. These findings collectively suggest that the combination of farnesyltransferase inhibitors and gamma-secretase inhibitors is a promising therapeutic strategy for glioblastoma through selectively targeting the cancer stem cell subpopulation. PMID: 29198824
    2. Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit PMID: 28948621
    3. our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability PMID: 22160308
    4. Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site. PMID: 15451670
    5. Geranylgeranyltransferase inhibitor-2147 (GGTI-2147), an inhibitor of protein prenylation, elicited significant inhibition of glucose-stimulated insulin secretion from INS 832/13 islet cells. PMID: 17192483
    6. FTase, via its tubulin-association, is a critical upstream regulator of HDAC6 activity PMID: 19228685

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  • 蛋白家族：
    Protein prenyltransferase subunit alpha family
  • 數據庫鏈接：

    HGNC: 3782

    OMIM: 134635

    KEGG: hsa:2339

    STRING: 9606.ENSP00000303423

    UniGene: Hs.370312