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  4. IQGAP2 Recombinant Monoclonal Antibody

IQGAP2 Recombinant Monoclonal Antibody

  • 中文名稱：
    IQGAP2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA440398A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of IQGAP2 expression in HeLa cells using IQGAP2 antibody. Green, isotype control; red, IQGAP2.
    • Immunocytochemical staining of HeLa cells with IQGAP2 antibody. Nuclei were stained blue with DAPI; IQGAP2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
    • Western blotting analysis using IQGAP2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with IQGAP2 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    IQGAP2; IQ Motif Containing GTPase Activating Protein 2; Ras GTPase-Activating-Like Protein IQGAP2
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human IQGAP2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6D12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
  • 基因功能參考文獻：
    1. IQGAP2 expression correlated positively with survivability, on the contrary, IQGAP3 expression levels correlated inversely with survivability PMID: 29073199
    2. The structural basis for Cdc42-induced dimerization of IQGAP1 and IQGAP2 has been uncovered. PMID: 27524202
    3. The most frequently identified and connected to preterm birth genes in the exome library were IGF1, ATM and IQGAP2. PMID: 27163930
    4. IQGAP2 TagSNP rs457717 (A/G) was not associated with Age-Related Hearing impairment in Han male Chinese population. PMID: 26187738
    5. Thus, these data identified IQGAP2 as a novel tumor suppressor for ovarian cancer to inhibit cell invasion through regulating Wnt/b-catenin signaling, and provided a new biomarker and potential therapeutic strategy for this disease. PMID: 26549344
    6. we identified IQGAP2 as a human and zebrafish podocyte gene product that is downregulated in microarray data sets from kidney biopsies of human patients with focal segmental glomerulosclerosis and minimal change nephrotic syndrome. PMID: 26154927
    7. Data show that IQ motif-containing GTPase-activating protein 2 (IQGAP2) expression is altered in colitis. PMID: 26047140
    8. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardiovascular system, pancreas, and lung. (Review) PMID: 25722290
    9. Mammalian IQGAP proteins may play a role in cytokinesis by regulating the localization of key cytokinesis regulatory proteins to the contractile apparatus during mitosis. PMID: 25229330
    10. Low IQGAP2 expression was associated with hepatocellular carcinoma. PMID: 24998570
    11. The first IQ-motifs from IQGAP2 and IQGAP3 form transient interactions with calmodulin in the absence of calcium. PMID: 21299499
    12. observations strongly indicate that IQGAP2 is a surveillance type of tumour suppressor for prostate cancer PMID: 22406297
    13. increased IQGAP1 and/or decreased IQGAP2 contribute to the pathogenesis of human HCC. PMID: 20977743
    14. The top-ranked SNP, rs457717 for association with age-related hearing impairment(P-value 3.55 x 10(-7)), was localised in an intron of the IQ motif-containing GTPase-activating-like protein (IQGAP2). PMID: 20068591
    15. The gene for the putative rac1/cdc42 effector protein IQGAP2 was found in the PAR gene cluster at 5q13, flanked by PAR1 & encompassing PAR3. It functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. PMID: 12515716
    16. silencing of IQGAP2 by promoter methylation may contribute to gastric cancer development. PMID: 17957782

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  • 組織特異性：
    Isoform 2 expression is enhanced in testis.
  • 數據庫鏈接：

    HGNC: 6111

    OMIM: 605401

    KEGG: hsa:10788

    STRING: 9606.ENSP00000274364

    UniGene: Hs.291030