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  4. PPP2R5D Recombinant Monoclonal Antibody

PPP2R5D Recombinant Monoclonal Antibody

  • 中文名稱：
    PPP2R5D Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA547865A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of PPP2R5D expression in HepG2 cells using PPP2R5D antibody. Green, isotype control; red, PPP2R5D.
    • Immunocytochemical staining of HepG2 cells with PPP2R5D antibody. Nuclei were stained blue with DAPI; PPP2R5D was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
    • Western blotting analysis using PPP2R5D? antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with PPP2R5D antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    PPP2R5D; Protein Phosphatase 2 Regulatory Subunit B'Delta; Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Delta Isoform; B56delta; B56D; Protein Phosphatase 2, Regulatory Subunit B (B56), Delta Isoform; PP2A B Subunit Isoform PR61-Delta; PP2A B Subunit Isoform B56-Delta; PP2A B Subunit Isoform B'-Delta; PP2A B Subunit Isoform R5-Delta; MRD35; HJS1
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human PPP2R5D protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    23B10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
  • 基因功能參考文獻：
    1. Mutations in PPP2R5D are genetic cause of intellectual disability. PMID: 26576547
    2. MiR-9 regulates GR signaling and steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity. PMID: 25772595
    3. Mutant B56delta was A and C binding-deficient, while mutant Aalpha subunits bound B56delta well but were unable to bind C PMID: 26168268
    4. PP2A-B56delta is the single most significant contributor, of the PP2A holoenzyme subunits, to BubR1 and Bub1 kinetochore localization. PMID: 25246613
    5. Protein kinase A mediated activation of protein phosphatase 2A is enabled by PPP2R5D phosphorylation, which modulates the affinity of the protein phosphatase 2A holoenzyme to its physiological substrates. PMID: 20423611
    6. Data show that the protein phosphatase 2A subunit B56delta specifically interacts with HAND1 and -2, but not other basic helix-loop-helix proteins. PMID: 14636580
    7. Gonadotropin-releasing hormone (GnRH) affects the membrane protein phosphatase 2A-associated apoptosis and the enzyme activity in ovarian cancer cells. PMID: 15809743
    8. PP2A:B56delta as a key upstream regulator of Cdk1 activity upon exit from mitosis PMID: 18056802

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  • 相關疾病：
    Mental retardation, autosomal dominant 35 (MRD35)
  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.
  • 蛋白家族：
    Phosphatase 2A regulatory subunit B56 family
  • 組織特異性：
    Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.
  • 數據庫鏈接：

    HGNC: 9312

    OMIM: 601646

    KEGG: hsa:5528

    STRING: 9606.ENSP00000417963

    UniGene: Hs.533308