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  4. TRIP10 Recombinant Monoclonal Antibody

TRIP10 Recombinant Monoclonal Antibody

  • 中文名稱：
    TRIP10 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA923451A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of thyroid hormone receptor interactor 10 expression in C2C12 cells using thyroid hormone receptor interactor 10 antibody. Green, isotype control; red, thyroid hormone receptor interactor 10.
    • Immunocytochemical staining of C2C12 cells with Thyroid hormone receptor interactor 10 antibody. Nuclei were stained blue with DAPI; Thyroid hormone receptor interactor 10 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using thyroid hormone receptor interactor 10 antibody. Total cell lysates (10 μg for NIH/3T3 and 40 μg for others) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with thyroid hormone receptor interactor 10 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    TRIP10; Thyroid Hormone Receptor Interactor 10; HSTP; CIP4; STP; STOT; Thyroid Receptor-Interacting Protein 10; Cdc42-Interacting Protein 4; TR-Interacting Protein 10; Salt Tolerant Protein; Salt Tolerator; Protein Felic; TRIP-10; Cdc42-Interacting Protein
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human TRIP10 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    20E12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
  • 基因功能參考文獻：
    1. Data show that CIP4 is highly expressed in nasopharyngeal carcinoma (NPC) tissues and is associated with poor prognosis. Also, the study provides evidence that CIP4 plays an important role in the promotion of NPC metastasis by mediating invadopodia formation and activating the EGFR pathway. PMID: 28129778
    2. results support a model in which AKAP350 recruits CIP4 to the centrosome, providing a centrosomal scaffold to integrate microtubule and actin dynamics, thus enabling centrosome polarization and ensuring cell migration directionality. PMID: 26208639
    3. CIP4 promotes metastasis in Triple negative breast cancer and is associated with poor prognosis. PMID: 25823823
    4. CIP4 is a positive regulator of non small lung carcinoma metastasis and a potential poor prognostic biomarker in lung adenocarcinoma. PMID: 25174397
    5. CIP4 controls cell-cell cohesion and is required for the acquisition of an invasive phenotype in breast tumors PMID: 25203208
    6. CIP4 plays a significant role in the intracellular hypertrophic signal transduction network that controls the growth of cardiac myocytes in heart disease. PMID: 23915320
    7. Study reveals a critical role of CIP4 in mediating chemotaxis of CLL cells by controlling the dynamics of microspike-containing protrusions and cell steering. PMID: 23644527
    8. Trip10 regulates cancer cell growth and death in a cancer type-specific manner. Differential DNA methylation of Trip10 can either promote cell survival or cell death in a cell type-dependent manner. PMID: 21299869
    9. CIP4 overexpression is associated with breast cancer. PMID: 20940394
    10. Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms PMID: 12054674
    11. CIP4 accumulation and cellular toxicity may have a role in Huntington's disease pathogenesis PMID: 12604778
    12. These results indicate that CIP4 is critical for beta-catenin-mediated cell-cell adhesion. PMID: 16343437
    13. Data showed the SH3 domain of CIP4 was bound to DAAM1 in vivo. PMID: 16630611
    14. CIP4 is an important cytoskeletal adaptor that functions after filamentous actin accumulation and Cdc42 activation to enable microtubule organizing center polarization and NK cell cytotoxicity PMID: 17785506
    15. Cdc42-Interacting Protein-4 and FNBP1L protein potentially regulate later events in Epidermal Growth Factor Receptor endocytic trafficking that limits compartmentalized EGFR signaling. PMID: 19632321
    16. FNBP1 family proteins (FNBP1 and TRIP10) consist of FCH, FBH and SH3 domains. PMID: 12736724

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup.; [Isoform 5]: Cytoplasm, perinuclear region.
  • 蛋白家族：
    FNBP1 family
  • 組織特異性：
    Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
  • 數據庫鏈接：

    HGNC: 12304

    OMIM: 604504

    KEGG: hsa:9322

    UniGene: Hs.515094