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  4. Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial (Active)

Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial (Active)

In Stock
  • 品名簡稱：
    Recombinant Human SIRPB1 protein, partial (Active)
  • 貨號：
    CSB-MP021335HUd7
  • 說明書：
  • 規格：
    ￥828
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Activity
      Measured by its binding ability in a functional ELISA.Immobilized Human SIRPB1 at 2 μg/ml can bind anti-SIRPB1 recombinant antibody(CSB-RA021335MA1HU).The EC50 is 0.9675-1.114 ng/mL. Biological Activity Assay
    • Activity
      SIRPB1 Recombinant Monoclonal Antibody(CSB-RA021335MA1HU) captured on Protein A Chip can bind Human SIRPB1 with an affinity constant of 0.245 nM as detected by MetaSPR Assay (WeSPRTM 200). Biological Activity Assay
    • The purity of SIRPB1 was greater than 95% as determined by SEC-HPLC
  • 其他：

產品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.
  • 內毒素：
    Less than 1.0 EU/ug as determined by LAL method.
  • 生物活性：
    ①Measured by its binding ability in a functional ELISA.Immobilized Human SIRPB1 at 2 μg/mL can bind anti-SIRPB1 recombinant antibody(CSB-RA021335MA1HU).The EC50 is 0.9675-1.114 ng/mL.
    ②SIRPB1 Recombinant Monoclonal Antibody(CSB-RA021335MA1HU) captured on Protein A Chip can bind Human SIRPB1 with an affinity constant of 0.245 nM as detected by MetaSPR Assay (WeSPRTM 200).
  • 基因名：
  • Uniprot No.：
  • 別名：
    Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD antigen CD172b
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    Mammalian cell
  • 分子量：
    38.6 kDa
  • 表達區域：
    30-371aa
  • 氨基酸序列
    EDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDITHEAALAPTAPL
  • 蛋白標簽：
    C-terminal 10xHis-tagged
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.
  • 基因功能參考文獻：
    1. SIRPB1 copy-number polymorphism was significantly associated with impulsive-disinhibited personality scores in a dose-dependent manner. PMID: 25039969
    2. SIRPbeta1 is a novel IFN-induced microglial receptor that supports clearance of neural debris and Abeta aggregates by stimulating phagocytosis. PMID: 19893026
    3. SIRP beta 1 is a disulfide-linked homodimer in leukocytes that regulates neutrophil transepithelial migration PMID: 16081415
    4. This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia. PMID: 19034380
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected in monocytes and dendritic cells.
  • 數據庫鏈接：

    HGNC: 15928

    OMIM: 603889

    UniGene: Hs.664861