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  4. Recombinant Mouse Ras-related C3 botulinum toxin substrate 2 (Rac2)

Recombinant Mouse Ras-related C3 botulinum toxin substrate 2 (Rac2)

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  • 中文名稱：
    Recombinant Mouse Ras-related C3 botulinum toxin substrate 2 (Rac2)
  • 品名簡稱：
    Recombinant Mouse Rac2 protein
  • 貨號：
    CSB-EP019248MO
  • 說明書：
  • 規格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 別名：
    Protein EN-7;p21-Rac2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    28.0 kDa
  • 表達區域：
    1-189aa
  • 氨基酸序列
    MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKDIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRPC
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 6xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
  • 基因功能參考文獻：
    1. These data reveals an intricate balance between activation of WASp and Rac2 signalling pathways in dendritic cells. PMID: 27425374
    2. Rac2 signaling axis is critical in the regulation of macrophage differentiation and lung fibrosis in vivo. PMID: 28817691
    3. Rac2 GTPase is activated downstream of alpha4beta1 integrin and the MCSF receptor to control tumor growth, metastasis and macrophage differentiation. PMID: 24770346
    4. Rac2-deficient animals have higher rates of mortality in pulmonary fibrosis. PMID: 24970330
    5. the levels of beta-catenin were reduced and not able to prevent the negative effect of Rac2 on PLD2 activity PMID: 23898047
    6. Rac2 is essential for NET formation via pathways involving ROS and NO. PMID: 21712395
    7. Rac2 drives the physiological process of late chemotaxis, and has a dual (enhancing and inhibitory) effect on PLD2-induced chemotaxis. PMID: 21444720
    8. Rac2(-/-) osteoclasts showed a marked defect in chemotaxis toward a point source of CSF1, with a dramatic reduction in migratory rate. PMID: 21110188
    9. Sbds is required for osteoclastogenesis by regulating monocyte migration via Rac2 and osteoclast differentiation signaling downstream of RANK. PMID: 21084708
    10. Data show that Rac2 deficiency exhausts the LSC pool in vivo through impairment of oncogene-induced proliferation and survival signals. PMID: 20407032
    11. Rac2 is directly implicated in the regulation of signaling thresholds for ligation of B cell antigen receptors and CD19, and the regulation of chemokine responses that determine the distribution of B cell populations. PMID: 11907095
    12. Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T Helper 1 responses. PMID: 12067410
    13. TRQQKRP motif in Rac2 protein is required for efficient prenylation and correct intracellular localization of Rac2 protein and is essential for Rac2 to mediate a variety of its biologic functions PMID: 12176888
    14. Rac2 regulates mast cell protease gene expression in bone marrow-derived mast cells PMID: 12370311
    15. Interleukin-3 (IL-3)-induced activation of endogenous Rac-2. PMID: 12384416
    16. Rac2 plays a dominant role in FMLP-activated neutrophil responses, reflecting a greater activation of Rac2 and a preferred role for Rac2 to stimulate downstream functional responses not compensated for by enhanced Rac1 activation of Rac2null neutrophils. PMID: 12391220
    17. evidence that the alpha4beta1 receptor in blood cells has evolved a Syk-Rac2 signaling axis to transmit signals required for integrin-directed migration suggesting that Syk kinase in part encodes myeloid Rac2 specificity in vivo PMID: 12917394
    18. specific sequences in Rac that specify subcellular localization and determine the specificity of Rac2 in neutrophil chemotaxis and superoxide generation PMID: 15170212
    19. confirm that Rac2 is the primary regulator of actin assembly providing the molecular motor for neutrophil translocation during chemotaxis PMID: 15308574
    20. Genetic evidence is provided that although Rac2 is a relatively minor isoform in murine macrophages, it plays a nonoverlapping role with Rac1 to regulate host defense functions in this phagocyte lineage. PMID: 15528331
    21. Rac2(-/-) stem/progenitor cells exhibit abnormal interaction with the hematopoietic microenvironment, which leads to defective long-term engraftment. PMID: 15749928
    22. Rac2 controls chemotaxis and superoxide production via distinct pathways and is critical for development of myeloid colonies in vitro PMID: 15814684
    23. Rac2 has a positive charge-independent mechanism in which Rac2 initially targets to endomembranes and then these endomembranes fuse to the phagosome. PMID: 16081809
    24. Rac2 significantly contributes to oxidant production at the wound site and supports the healing process. PMID: 18068132
    25. critical role for Rac2 in mediating B cell adhesion PMID: 18191593
    26. In the genetic absence of Rac2, the anabolic response to PTH is increased. PMID: 18467443
    27. Rac2 in hematopoietic cells regulates leukocyte lineage distribution and Rac2 in nonhematopoietic cells might contribute to regulating circulating neutrophil counts. PMID: 18583316
    28. PI3K and Src-ELMO-Dock2 pathways work in parallel to activate Rac2 and modulate chemotaxis in response to a CXCL8 gradient in neutrophils. PMID: 18662984
    29. RAC2 in vascular endothelial cells is obligately required for the postnatal neovascular response and alphavbeta3/ alpha4beta1/alpha5beta1 integrin-directed migration on vitronectin, H296 and CH271, fibronectin fragments, respectively. PMID: 19123268
    30. Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth. PMID: 19151256
    31. GTPase Rac2 plays a critical role in antigen crosspresentation selectively in this dendritic cell subpopulation PMID: 19328020
    32. cells. Results showed that immortalized WT2 cells were able to differentiate into mature, multinucleated, functional, tartrate-resistant acid phosphatase-positive osteoclasts. PMID: 19649754
    33. Lung injury in response to immune complex deposition is dependent on Rac2 in alveolar macrophages and neutrophils. PMID: 19801448

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  • 亞細胞定位：
    Cytoplasm. Membrane; Lipid-anchor.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 數據庫鏈接：

    KEGG: mmu:19354

    STRING: 10090.ENSMUSP00000036384

    UniGene: Mm.1972