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  4. Recombinant Vaccinia virus Protein A46 (VACWR172)

Recombinant Vaccinia virus Protein A46 (VACWR172)

  • 中文名稱：
    Recombinant Vaccinia virus Protein A46 (VACWR172)
  • 貨號：
    CSB-YP326310VAI
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Vaccinia virus Protein A46 (VACWR172)
  • 貨號：
    CSB-EP326310VAI
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Vaccinia virus Protein A46 (VACWR172)
  • 貨號：
    CSB-EP326310VAI-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Vaccinia virus Protein A46 (VACWR172)
  • 貨號：
    CSB-BP326310VAI
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Vaccinia virus Protein A46 (VACWR172)
  • 貨號：
    CSB-MP326310VAI
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    VACWR172
  • Uniprot No.：
  • 別名：
    VACWR172; A46RProtein A46
  • 種屬：
    Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-240
  • 氨基酸序列
    MAFDISVNAS KTINALVYFS TQQNKLVIRN EVNDTHYTVE FDRDKVVDTF ISYNRHNDTI EIRGVLPEET NIGCAVNTPV SMTYLYNKYS FKLILAEYIR HRNTISGNIY SALMTLDDLA IKQYGDIDLL FNEKLKVDSD SGLFDFVNFV KDMICCDSRI VVALSSLVSK HWELTNKKYR CMALAEHISD SIPISELSRL RYNLCKYLRG HTESIEDKFD YFEDDDSSTC SAVTDRETDV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    BCL2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Acts close to the plasma membrane and targets several host TIR-domain containing adaptor proteins including MYD88, TIRAP, TRIF and TICAM2. In turn, blocks the host NF-kappa-B and TRIF-mediated IRF3 activation.
  • 基因功能參考文獻：
    1. Results show that A46 is a homodimer with a Bcl-2-like fold and VIPER motif is believed to be involved in the interaction with MAL protein. PMID: 24723367
    2. Characterization and structure of the vaccinia virus NF-kappaB antagonist A46. PMID: 24356965
    3. The region of A46 from which VIPER is derived represents the TLR4-specific inhibitory motif of the intact protein, and is essential for A46:TRAM interactions. PMID: 22593572
  • 蛋白家族：
    Poxviridae A46R protein family
  • 數據庫鏈接：

    KEGG: vg:3707702