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  4. Recombinant Mouse Type-2 angiotensin II receptor (Agtr2)

Recombinant Mouse Type-2 angiotensin II receptor (Agtr2)

  • 中文名稱：
    Recombinant Mouse Type-2 angiotensin II receptor(Agtr2)
  • 貨號：
    CSB-CF001466MO(A4)
  • 規格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Agtr2Type-2 angiotensin II receptor; Angiotensin II type-2 receptor; AT2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-363aa
  • 氨基酸序列
    MKDNFSFAATSRNITSSRPFDNLNATGTNESAFNCSHKPSDKHLEAIPVLYYMIFVIGFA VNIVVVSLFCCQKGPKKVSSIYIFNLALADLLLLATLPLWATYYSYRYDWLFGPVMCKVF GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKGSSLREMDT FVS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    10xHis-SUMO-tag
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
  • 基因功能參考文獻：
    1. Study showed that in type 1 diabetes, angiotensin II type 2 receptor may reduce glycaemia and display anti-oxidant and/or anti-inflammatory properties in association with greater vasodilatation in mesenteric arteries and in the renal vasculature, a major target of diabetes. PMID: 28361992
    2. the expression of AT2 receptors was significantly increased compared to that of AT1 receptors upon ischemic induction. PMID: 29710550
    3. study identifies AT2R on peripheral MPhis as a critical trigger for pain sensitization at the site of nerve injury, and therefore proposes a translatable peripheral mechanism underlying chronic neuropathic pain. PMID: 30082378
    4. Data suggest that the anticoagulant effects of rivaroxaban are promoted by angiotensin II via angiotensin type 2 receptor and Mas signaling. These findings are significant for the clinical administration of rivaroxaban. PMID: 28337024
    5. crosstalk between AT2 receptor stimulation and PPARgamma activation could contribute to attenuation of vascular intimal proliferation PMID: 26471325
    6. Deletion of AT2 receptor reduced SHP-1 activity and restored VEGF actions, leading to an increased blood flow reperfusion after ischemia in diabetes mellitus. PMID: 29074590
    7. Our current results reinforce the notion that the AT2R has a physiological role in the conservation of insulin action PMID: 27979738
    8. Ultra-high doses did not influence the ACE2/AT2R/Mas axis and promoted renal injury with increased renal ERK1/2 activation and exaggerated fibronectin expression in db/db mice. Our study demonstrates dose-related effects of candesartan in diabetic nephropathy: intermediate-high dose candesartan is renoprotective, whereas ultra-high dose candesartan induces renal damage. PMID: 27612496
    9. This study aimed to define whether sex chromosome complement (SCC) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2, and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney. PMID: 28254489
    10. loss of AT2 R is associated with podocyte loss/dysfunction and is mediated, at least in part, via augmented ectopic hedgehog interacting protein expression in podocytes PMID: 28722118
    11. AT2R-dependent interleukin-17 production by T lymphocyte is necessary for collateral artery growth. PMID: 27328880
    12. Altered expression of AT1 and AT2 receptors with aging may induce mitochondrial dysfunction, the main risk factor for neurodegeneration. PMID: 27763643
    13. AT2R inhibits adipogenic differentiation in mesenchymal stem cells. Moreover, this inhibitory effect is associated with Wnt10b/beta-catenin signaling. PMID: 27295344
    14. These results suggest that nerve growth factor-mediated neurite outgrowth is suppressed by AT2 receptor signaling via the nitric oxide-cyclic GMP-PKG pathway. PMID: 27524238
    15. AT2R expressing neurons make GABAergic synapses onto AVP neurons that inhibit AVP neuronal activity and suppress baseline systemic AVP levels. PMID: 27267713
    16. Further deletion/mutation analysis revealed that multiple transcription factor binding sites in the +286/+690 region within intron 2 coordinately regulate AT2R transcription. Importantly, +286/+690 enhancer activity was suppressed in CHF mouse skeletal muscle, suggesting that AT2R expression is suppressed in CHF via inhibition of AT2R intronic enhancer activity, leading to lowered muscle regeneration. PMID: 27756842
    17. This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR. PMID: 27496559
    18. Hypercholesterolemia blunts the oxidative stress and inflammatory cell recruitment elicited by hypertension in venules through a mechanism that involves AT2 receptor activation. PMID: 26775070
    19. These results suggest that in the absence of AT2R, wound healing rate is accelerated, but yielded worse skin quality. PMID: 26727887
    20. Bone marrow-AT2 deficiency aggravates atherosclerosis, at least in part, by eliminating the anti-atherogenic properties of macrophages elicited by LXRbeta activation. PMID: 25487979
    21. the possible roles of AT2 receptor-mediated dopamine regulation in the pathogenesis of Binge eating disorder, was investigated. PMID: 25757658
    22. AT2R signaling positively regulates myoblast differentiation and potentiates skeletal muscle regenerative potential. PMID: 25112871
    23. The functional activities of AT2R is time-dependently modulated under hypoxia in the central nervous system in comparison with the adrenal glands. PMID: 23515786
    24. AT2R expression may contribute to pregnancy-induced hypertension and thus represents a potential therapeutic target. PMID: 24935937
    25. These data revealed an AT2 receptor-mediated mechanism regulating pancreatic endocrine cell development in vivo. PMID: 24166718
    26. Data suggest that AT2 receptor affects postnatal cardiac growth possibly via reducing body weight gain and systemic blood pressure. PMID: 23144713
    27. Data suggest that whether overexpression of angiotensin II type 2 receptor AT2R is beneficial or detrimental to the heart is largely dependent on expression levels. PMID: 24732892
    28. The present study shows that the angiotensin system, especially that involving AT2R, may have an oxidative injury-potentiating effect via augmentation of the activity of NADPH oxidase. PMID: 24289788
    29. Direct stimulation of the angiotensin II type 2 receptor improves endothelial function and reduces atherosclerotic plaque progression. PMID: 24161533
    30. blockade of the AT1 receptor by azilsartan could enhance the activities of the ACE2/Ang-(1-7)/Mas axis and ACE2/Ang-(1-7)/AT2 receptor axis, thereby inhibiting neointimal formation. PMID: 24379178
    31. The levels of AT-2 but not AT-1 receptor are modulated by the pro-fibrotic factor TGFB1 in myoblasts and mouse skeletal muscle. PMID: 23460581
    32. Electrophysiological and molecular properties of control and AT2 R-stimulated cells point to a differentiation to vascular endothelial cells. PMID: 23648269
    33. AT(2)R in female mice via potentially regulating estrogen may have protective role against body weight gain and impaired glucose tolerance and lipid metabolism. PMID: 23341867
    34. These data imply an involvement of AT1R in fetal development and of AT2R in adult function. PMID: 22526820
    35. Up-regulation of AT1R promotes inflammation and LOX-1 expression, whereas up-regulation of AT2R promotes apoptosis signals and decreases LOX-1 expression. PMID: 23354398
    36. AT1 receptor might be closely associated with cell proliferation, while AT2 receptor might play a role in cell apoptosis and remodeling during wound healing. PMID: 21774352
    37. In the absence of B2R, both B1R and AT2R play important compensatory roles in preventing deterioration of cardiac function and remodelling post-myocardial infarction. PMID: 22849668
    38. in mice with memory impairment due to cholinergic hypofunction, AT2 receptors had no effect on memory, but they became dominant when AT1 receptor was blocked PMID: 22362194
    39. study found activation of ATreceptors stimulates apelin secretion in Ca(2), protein kinase C and MAPK kinase dependent ways; activation of AT receptors inhibits apelin secretion through cAMP and cGMP dependent pathways; expression of apelin receptor is si PMID: 22249006
    40. AT(2)R-mediated eNOS NO production and vasorelaxation through a MEK pathway are enhanced in aortas from db/db mice. PMID: 22465219
    41. Angiotensin II modulates Vegf-induced angiogenesis through opposing effects of angiotensin II receptor type 1 and type 2. PMID: 22374305
    42. Both up-regulation and/or blockade of AT2R contributed to the altered course of HIV-associated nephropathy. PMID: 22108089
    43. Podocytes of AT2 receptor knockout mice are protected from angiotensin II-mediated RAGE induction PMID: 21846974
    44. Enhanced AT(2)R-mediated pathway counterbalances the hypertensive effects of Angiotensin II and attenuates the Ang II-dependent resetting of tubuloglomerular feedback activity in females. PMID: 22124434
    45. Ang-II responses were also greater during pregnancy, with an increased contraction in response to AT2 receptor blockade at mid-gestation. PMID: 21421654
    46. Results indicate that deletion of AT(2) receptor in blood cells has a harmful effect on ischemic brain injury. PMID: 21768524
    47. There is no consistent relationship between changes in tissue angiotensin II receptor mRNA expression and systolic blood pressure in WT mice. PMID: 20739375
    48. The different genetically modified mouse models used to study the AT(2) receptor and its association with cardiac hypertrophy and heart failure, were reviewed. PMID: 21541238
    49. Report expression of Agtr2 in pregnancy-induced uterine natural killer cells (uNK) at gestational days 5-12. PMID: 20959647
    50. findings show loss of AT2 expression accelerates aberrant growth and rupture of the aorta in model of Marfan syndrome; AT2 signaling attenuates aortic aneurysm in mice through ERK1/2 antagonism PMID: 21493863

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Expressed at highest levels in adrenal gland and uterus.
  • 數據庫鏈接：

    KEGG: mmu:11609

    STRING: 10090.ENSMUSP00000086592

    UniGene: Mm.2679