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  4. Recombinant Rat Calcium release-activated calcium channel protein 1 (Orai1)

Recombinant Rat Calcium release-activated calcium channel protein 1 (Orai1)

  • 中文名稱：
    大鼠Orai1重組蛋白
  • 貨號：
    CSB-CF689622RA
  • 規格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Orai1; Cracm1; Tmem142a; Calcium release-activated calcium channel protein 1; Protein orai-1; Transmembrane protein 142A
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-304
  • 氨基酸序列
    MHPEPAPPPNNSNPELPLSGGSSTSGSRRSRRRSGDGEPTGAPPLPPPPAVSYPDWIGQS YSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTDHDYPPGL LIVFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFS TVIGTLLFLAEVVLLCWVKFLPLKRQAGQPSPTKPPTEPAVVVANSSNNGGITPGEAAAI ASTAIMVPCGLVFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHSLTPG THYA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion.
  • 基因功能參考文獻：
    1. the declined Orai1 expression, at least partly, contributes to the downregulated Ca(2+) entry during lymphocyte excitation, providing an important mechanism for T lymphocyte malfunction in diabetes. PMID: 29654766
    2. Store operated calcium channels are associated with diabetic cystopathy in streptozotocininduced diabetic rats. PMID: 29532875
    3. these results demonstrated that NEFA-sensitive NFkappaB-dependent Orai1 expression regulates de novo lipogenesis. PMID: 29913436
    4. Using dominant negative form of ORAI1, we were able to show that ORAI1 is needed for formation of new dendritic spines following chemical induction of long term potentiation (cLTP), and that this is due to the release of Ca(+2) from ryanodine receptor-associated endoplasmic reticulum stores. PMID: 28189550
    5. Hypertrophic aortic remodeling and abnormal contraction triggered mainly by Ca2+ overload via STIM-1/Orai-1-mediated SOCE through SOCCs are involved hypertension developed by EtOH consumption. PMID: 28155613
    6. Ang-II-induced Egr-1 expression is mediated by STIM-1/Orai-1/Ca(2+) -dependent signaling pathways in vascular smooth muscle cells. PMID: 28105751
    7. Influx of calcium through Orai1 channels facilitates the maturation of dendritic spines and the formation of functional synapses in central neurons PMID: 27393042
    8. Neuronal aging is associated to increased ER-mitochondrial cross talking and loss of store-operated calcium entry via Stim1/Orai1. PMID: 27503411
    9. in endotoxemia, Ca(2+) homeostasis is disrupted in VSMC, with decreased Ca(2+) influx, smaller concentrations of Ca(2+) in the sarcoplasmic reticulum, and decreased activation of Orai1 PMID: 27099074
    10. store-operated calcium entry may play a critical role in severe acute pancreitis-associated acute lung injury; and the protective effects of inhibition of SOC proteins Orai1 and STIM1 could be mediated, at least partially, by restraining mitochondrial associated apoptosis of pulmonary microvascular endothelial cells PMID: 27025854
    11. Orai1 gene expression is upregulated by aldosterone in rat cardiomyocytes. PMID: 27129253
    12. Orai1 forms a complex with BKCa in the mesenteric artery smooth muscle. PMID: 26755740
    13. Stim1/Orai1 function was altered in vascular smooth muscle from mesenteric arteries and aorta with aging. PMID: 25636074
    14. STIM1/Orai1 blockade could alleviate alcohol-induced hepatotoxicity by inhibiting apoptosis. PMID: 26033013
    15. Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia. PMID: 25540197
    16. Demonstrate that sodium permeates activated store-operated calcium entry channels, resulting in an increase in cytosolic sodium; the magnitude of this response is determined by Orai1. PMID: 25428882
    17. This study demonistrated that inhibition of orai1 expression and decreased the intracellular calcium concentration in neurons. PMID: 24509424
    18. the attenuation of GMCs proliferation can be attributed to the decreased SOCE partially caused by reduced expression of STIM 1 and Orai 1. PMID: 23334602
    19. The second coiled-coil domain of STIM1 is required for coupling to either Orai3 or Orai3/Orai1 channels. PMID: 23878392
    20. We show in neuronal somata the formation of endogenous complexes of stromal interaction molecule 2 (STIM2) with ORAI1 calcium channels PMID: 23711249
    21. Orai channels are activated by different agonists/pathways and uncover a mechanism whereby leukotrieneC4 acts through hitherto unknown intracrine mode to elicit store-independent Ca(2+) signaling that promotes vascular occlusive disease. PMID: 23349245
    22. The overexpression of Orai1 increased by twofold the Ca(2+) influx evoked by thrombin, while knockdown of endogenous Orai1 significantly decreased this Ca(2+) influx. PMID: 22944608
    23. Report Orai1 expression in hippocampal neurons in response to corticosterone. PMID: 23169006
    24. we show that Ca(2+) influx via Orai1 plays an important role in regulating spontaneous motility and directional migration of mast cells PMID: 22859829
    25. Knockdown of the genes encoding Trpc1, Orai1 and Stim1, but not Trpc6, substantially reduced the frequency (up to 60%) of PGF(2alpha)-induced Ca(2+) oscillations in normal rat kidney cells. PMID: 22050845
    26. Stim1- and Orai1-mediated store-operated calcium entry is critical for angiotensin II-induced vascular smooth muscle cell proliferation. PMID: 22108917
    27. Calcium entry via ORAI1 is important for glioblastoma proliferation and survival PMID: 21945734
    28. Augmented activation of STIM1/Orai1 in aortas from male SHRSP represents a mechanism that contributes to sex-related impaired control of intracellular Ca2+ levels. PMID: 21966957
    29. Store-depletion-stimulated STIM1-Orai1 association is positively regulated by the ordered lipid pool of PtdIns(4,5)P(2) and negatively regulated by PtdIns(4,5)P(2) in disordered lipid domains. PMID: 21750194
    30. Orai1 is upregulated in vascular smooth muscle cells (VSMC) during vascular injury and is required for VSMC proliferation and neointima formation following balloon injury of rat carotids. PMID: 21737791
    31. suppression of store-operated channels function by Orai1 overexpression likely reflects a required stoichiometry between STIM1 and Orai1 [Orai1] PMID: 16766533
    32. dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in activation of SOC channel in response to internal Ca2+ store depletion. PMID: 17224452
    33. These results suggested that STIM1/Orai1-mediated SOCE is involved in ASMC proliferation. PMID: 21330611
    34. both Orai1 and Stim1 have a key role in cardiomyocyte store operated Ca(2+) entry regulating both normal and hypertrophic postnatal cardiac growth in vitro PMID: 20138887
    35. STIM1 activation by store depletion or mutational modification suppresses Ca(V)1.2 channels while activating store-operated Orai channels; STIM1 interacts with and reciprocally controls 2 major calcium channels hitherto thought to operate independently PMID: 20929813
    36. These results establish the role of STIM1 and Orai1 in vascular smooth muscle cell movement and vascular injury repair. PMID: 20107038
    37. Data challenge the idea of direct conformational coupling between STIM1 and Orai1 as a viable mechanism of puncta formation and SOCE activation and uncover greater complexity in their relationship. PMID: 18768920
    38. Knockdown of Orai1 protein inhibits endothelial proliferation and causes cell cycle arrest at S and G2/M phase. PMID: 18845811
    39. Results reveal dynamic molecular interactions between STIM1 and Orai1/CRACM1 that depend quantitatively on electrostatic interactions and on the extent of store depletion. PMID: 18987344
    40. Both Orai-1 and STIM-1 contribute to abnormal vascular function in hypertension. Augmented activation of STIM-1/Orai-1 may represent the mechanism that leads to impaired control of intracellular Ca(2+) levels in hypertension. PMID: 19075091
    41. two cytosolic key regions within STIM1 C terminus that control ORAI1/CRAC activation: a homomerization domain indispensable for coupling to ORAI1 and a modulatory domain that controls the extent of coupling to ORAI1. PMID: 19189966
    42. Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration. PMID: 19364762

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Orai family
  • 數據庫鏈接：