TAFA5 (NS-101 Biosimilar) Recombinant Monoclonal Antibody

產(chǎn)品詳情

Uniprot No.：

Q7Z5A7
基因名：

TAFA5
別名：

NS101(Neuracle Science) research-grade biosimilar; RY103 research-grade biosimilar; RY-103 research-grade biosimilar ;TAFA5 antibody; FAM19A5 antibody; UNQ5208/PRO34524 antibody; Chemokine-like protein TAFA-5 antibody
反應(yīng)種屬：

Human
免疫原：

Recombinant Human TAFA5 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

0.01M PBS，pH7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用說明：

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

3-4 weeks
用途：

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

功能：

Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling. Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries.
亞細胞定位：

Secreted.
蛋白家族：

FAM19/TAFA family
組織特異性：

Expressed in the subcutaneous and perirenal adipose tissue (at protein level). Highly expressed in adipose tissue with moderate expression in the brain and ovary. Isoform 2: Brain-specific.
數(shù)據(jù)庫鏈接：

HGNC: 21592

OMIM: 617499

KEGG: hsa:25817

STRING: 9606.ENSP00000383933

UniGene: Hs.436854