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ADAM17

ADAM17(解整合素金屬蛋白酶17)又稱TACE(腫瘤壞死因子α轉化酶),是一種跨膜蛋白酶,主要參與細胞表面蛋白的裂解和信號傳導調控。ADAM17通過剪切多種膜錨定分子(如TNF-α、EGFR配體及Notch受體等),在炎癥反應、表皮生長及免疫調節中發揮關鍵作用。其活性異常與類風濕性關節炎、銀屑病等自身免疫疾病密切相關,同時也在結直腸癌、乳腺癌等惡性腫瘤的侵襲轉移過程中起促進作用。近年來研究發現,ADAM17可通過激活EGFR信號通路加速腫瘤細胞增殖,并與阿爾茨海默病中淀粉樣蛋白前體的加工存在潛在關聯。
針對ADAM17的藥物研發聚焦于抑制其蛋白酶活性,已有多個小分子抑制劑(如INCB7839、BMS-561392)進入臨床試驗階段,嘗試用于三陰性乳腺癌和急性髓系白血病的治療。單克隆抗體類藥物如MEDI3622則通過阻斷ADAM17與底物結合發揮作用,但部分藥物因影響生理功能而存在安全性問題,其特異性抑制策略和疾病適應癥仍在持續探索中。

熱銷產品

ADAM17 Recombinant Monoclonal Antibody (CSB-RA797631A0HU)

驗證數據

CSB-RA797631A0HU

Immunofluorescence staining of Hela Cells with CSB-RA797631A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

ADAM17 Antibodies

ADAM17 for Homo sapiens (Human)

ADAM17 Proteins

ADAM17 Proteins for Homo sapiens (Human)

ADAM17 Proteins for Sus scrofa (Pig)

ADAM17 ELISA Kit

ADAM17 ELISA Kit for Homo sapiens (Human)

ADAM17 ELISA Kit for Mus musculus (Mouse)