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AGO2

AGO2,全稱為Argonaute 2,也常被稱為EIF2C2,是RNA誘導(dǎo)沉默復(fù)合體(RISC)的核心組成部分。它在細(xì)胞內(nèi)的基因調(diào)控網(wǎng)絡(luò)中占據(jù)關(guān)鍵位置,能與微小RNA、小干擾RNA等小分子核酸緊密結(jié)合,精準(zhǔn)識別特定靶基因序列,進(jìn)而調(diào)控這些基因的表達(dá)水平,參與細(xì)胞增殖、分化、凋亡及代謝等多種基礎(chǔ)生命活動的調(diào)節(jié)。
在疾病領(lǐng)域,AGO2的異常表達(dá)或功能失調(diào)與多種病癥相關(guān):部分惡性腫瘤(如肺癌、乳腺癌)中,它的表達(dá)量明顯上升,可能推動腫瘤細(xì)胞的侵襲與轉(zhuǎn)移;此外,它在機體抗病毒防御中發(fā)揮作用,一些病毒會通過抑制AGO2的活性來逃避宿主免疫監(jiān)控。目前,針對AGO2的藥物研發(fā)尚處于早期探索階段,研究團(tuán)隊正致力于開發(fā)能調(diào)節(jié)其功能的小分子化合物或核酸類制劑,期望通過靶向這一蛋白來修復(fù)紊亂的基因調(diào)控,為癌癥、慢性病毒感染等疾病開辟新的治療方向。

熱銷產(chǎn)品

Recombinant?Human?Protein?argonaute-2 (AGO2), partial (CSB-EP891731HU)

驗證數(shù)據(jù)

CSB-EP891731HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP891731HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP891731HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) AGO2.

CSB-EP891731HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP891731HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) AGO2.

AGO2 Recombinant Monoclonal Antibody (CSB-RA965823A0HU)

驗證數(shù)據(jù)

CSB-RA965823A0HU

Immunofluorescence staining of MCF-7 with CSB-RA965823A0HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 492-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA965823A0HU

Overlay Peak curve showing Hela cells stained with CSB-RA965823A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

AGO2 Antibody (CSB-PA891731LA01HU)

驗證數(shù)據(jù)

CSB-PA891731LA01HU

Western Blot
Positive WB detected in: JK whole cell lysate(20μg), HepG2 whole cell lysate(20μg), K562 whole cell lysate(20μg), PC-3 whole cell lysate(20μg)
All lanes: AGO2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 98 kDa
Observed band size: 98 kDa
Exposure time:1min

CSB-PA891731LA01HU

IHC image of CSB-PA891731LA01HU diluted at 1:800 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

CSB-PA891731LA01HU

IHC image of CSB-PA891731LA01HU diluted at 1:800 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

CSB-PA891731LA01HU

IHC image of CSB-PA891731LA01HU diluted at 1:800 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

Human Protein argonaute-2(EIF2C2) ELISA kit (CSB-EL007520HU)

驗證數(shù)據(jù)

CSB-EL007520HU 標(biāo)準(zhǔn)曲線

貨號:CSB-EL007520HU

規(guī)格:96T/48T

靈敏度:6.25 pg/mL

檢測范圍:25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

AGO2 Antibodies

AGO2 for Homo sapiens (Human)

AGO2 Proteins

AGO2 Proteins for Homo sapiens (Human)

AGO2 ELISA Kit

AGO2 ELISA Kit for Homo sapiens (Human)