AP2M1
AP2M1，全稱為銜接蛋白2μ亞基，常被簡(jiǎn)稱為AP-2μ鏈。它是細(xì)胞內(nèi)AP2蛋白復(fù)合物的核心成員之一，這個(gè)復(fù)合物就像細(xì)胞的“內(nèi)吞搬運(yùn)隊(duì)”，負(fù)責(zé)將細(xì)胞表面的信號(hào)受體、營(yíng)養(yǎng)轉(zhuǎn)運(yùn)蛋白等分子“打包”送入細(xì)胞內(nèi)部，以此調(diào)控這些蛋白的活性和細(xì)胞對(duì)外界信號(hào)的反應(yīng)節(jié)奏。
疾病關(guān)聯(lián)上，它的功能異常可能引發(fā)多種問(wèn)題：比如在阿爾茨海默病中，AP2參與的內(nèi)吞過(guò)程可能與β淀粉樣蛋白的代謝失衡有關(guān)；部分癌癥研究顯示，AP2M1的表達(dá)變化可能干擾細(xì)胞生長(zhǎng)信號(hào)的正常調(diào)節(jié)，助推腫瘤細(xì)胞的異常增殖。目前針對(duì)它的藥物研發(fā)仍處于基礎(chǔ)探索階段，科研人員正深入解析它與復(fù)合物其他成分的相互作用模式，嘗試尋找能精準(zhǔn)調(diào)節(jié)其功能的小分子化合物，有望為相關(guān)疾病治療開(kāi)辟新靶點(diǎn)方向。
熱銷產(chǎn)品
Recombinant Human AP-2 complex subunit mu (AP2M1) (CSB-EP001872HUa0)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
AP2M1 Recombinant Monoclonal Antibody (CSB-RA937318A0HU)
驗(yàn)證數(shù)據(jù)
Immunocytochemical staining of C2C12 cells with AP2M1 antibody. Nuclei were stained blue with DAPI; AP2M1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
Western blotting analysis using AP2M1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with AP2M1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
AP2M1 Antibody (CSB-PA00625A0Rb)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: AP2M1 antibody at 2µg/ml
Lane 1: Jurket whole cell lysate
Lane 2: U87 whole cell lysate
Lane 3: U251 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 50 kDa
Observed band size: 50, 22 kDa
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA00625A0Rb at dilution of 1:100
AP2M1 Antibodies
AP2M1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA00625A0Rb | AP2M1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA00627A0Rb | AP2M1 Antibody | Human, Mouse, Rat | ELISA, WB, IHC |
| CSB-PA850274ESR1HU | AP2M1 Antibody | Human | ELISA, IHC |
| CSB-PA248529 | AP2M1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA227771 | AP2M1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA937318A0HU | AP2M1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, ICC |
AP2M1 Proteins
AP2M1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001872MO CSB-EP001872MO CSB-BP001872MO CSB-MP001872MO CSB-EP001872MO-B |
Recombinant Mouse AP-2 complex subunit mu (Ap2m1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AP2M1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001872RA CSB-EP001872RA CSB-BP001872RA CSB-MP001872RA CSB-EP001872RA-B |
Recombinant Rat AP-2 complex subunit mu (Ap2m1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AP2M1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP676978BO CSB-EP676978BO CSB-BP676978BO CSB-MP676978BO CSB-EP676978BO-B |
Recombinant Bovine AP-2 complex subunit mu (AP2M1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AP2M1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP687021MOV CSB-EP687021MOV CSB-BP687021MOV CSB-MP687021MOV CSB-EP687021MOV-B |
Recombinant Macaca fascicularis AP-2 complex subunit mu (AP2M1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AP2M1 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP702927PYX CSB-EP702927PYX CSB-BP702927PYX CSB-MP702927PYX CSB-EP702927PYX-B |
Recombinant Pongo abelii AP-2 complex subunit mu (AP2M1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AP2M1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP713773CH CSB-EP713773CH CSB-BP713773CH CSB-MP713773CH CSB-EP713773CH-B |
Recombinant Chicken AP-2 complex subunit mu (AP2M1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AP2M1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP754210XBF CSB-EP754210XBF CSB-BP754210XBF CSB-MP754210XBF CSB-EP754210XBF-B |
Recombinant Xenopus tropicalis AP-2 complex subunit mu (ap2m1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AP2M1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP773661XBE CSB-EP773661XBE CSB-BP773661XBE CSB-MP773661XBE CSB-EP773661XBE-B |
Recombinant Xenopus laevis AP-2 complex subunit mu (ap2m1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AP2M1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-EP001872HUe0 | Recombinant Human AP-2 complex subunit mu (AP2M1) | E.coli |
| CSB-EP001872HU | Recombinant Human AP-2 complex subunit mu (AP2M1) | E.coli |
| CSB-YP001872HU | Recombinant Human AP-2 complex subunit mu (AP2M1) | Yeast |
| CSB-BP001872HU CSB-MP001872HU CSB-EP001872HU-B |
Recombinant Human AP-2 complex subunit mu (AP2M1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP001872HUa0 | Recombinant Human AP-2 complex subunit mu (AP2M1) | E.coli |
