国产午夜福利片1000无码丨人妻国产成人久久av免费高清丨午夜做受视频试看6次丨日韩av不卡一区在线免费观看丨在线观看精品三级欧美

Your Good Partner in Biology Research

APEX2

DNA-is a protein in humans that is encoded by APEX2 gene. Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

APEX2 Proteins

APEX2 Proteins for Bos taurus (Bovine)

APEX2 Proteins for Mus musculus (Mouse)

APEX2 Proteins for Homo sapiens (Human)



主站蜘蛛池模板: 大足县| 金山区| 廊坊市| 万年县| 德安县| 九龙县| 衡阳县| 察隅县| 繁峙县| 正宁县| 泗阳县| 汽车| 遵义市| 吕梁市| 文登市| 泽普县| 武隆县| 张家界市| 迁西县| 文山县| 拉萨市| 永仁县| 青河县| 卓资县| 民乐县| 台江县| 都江堰市| 修文县| 湖州市| 德格县| 河北区| 黄浦区| 旌德县| 波密县| 教育| 宁海县| 黎川县| 晋州市| 尼木县| 平乐县| 安多县|