APRIL

APRIL，即增殖誘導配體，別名CD256、TNFSF13。它是一種主要由髓系細胞產生的蛋白質，包括常規樹突狀細胞、濾泡DC、單核細胞、中性粒細胞和巨噬細胞，活化的B細胞也少量產生APRIL。APRIL的作用機制涉及與其受體TACI、BCMA和HSPG的結合，通過這些相互作用參與調節B細胞的激活、漿細胞的存活以及免疫球蛋白的同種型轉換。APRIL在多種生理過程中發揮作用，包括B細胞的成熟、抗體的類別轉換以及長壽命漿細胞的形成。此外，APRIL在多種疾病中也有重要作用，包括自身免疫性疾病如系統性紅斑狼瘡(SLE)和IgA腎病(IgAN)，以及多種類型的癌癥，如乳腺癌、結直腸癌和非小細胞肺癌等。APRIL的異常表達與腫瘤細胞的增殖、存活和侵襲有關，使其成為潛在的治療靶點。

熱銷產品

TNFSF13 Antibody (CSB-PA023989ESR1HU)

驗證數據

Western blot
All lanes: Tumor necrosis factor ligand superfamily member 13 antibody at 10μg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 28, 26, 25, 37, 23 kDa
Observed band size: 28 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA023989ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA023989ESR1HU at dilution of 1:100

Human a proliferation inducing ligand(APRIL)ELISA Kit (CSB-E15012h)

驗證數據

貨號：CSB-E15012h

規格：96T/48T

靈敏度：0.195 ng/mL

檢測范圍：0.78 ng/mL-50 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

APRIL Antibody

APRIL Protein

APRIL ELISA Kit

APRIL Antibodies

APRIL for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA023989GA01HU	TNFSF13 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA023989ESR1HU	TNFSF13 Antibody	Human	ELISA, WB, IHC
CSB-PA023989ESR2HU	TNFSF13 Antibody	Human	ELISA, IHC
CSB-PA244663	TNFSF13 Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA000909	TNFSF13 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA877550	TNFSF13 Antibody	Human,Mouse	ELISA,IHC
CSB-PA935662	TNFSF13 Antibody	Human,Mouse	ELISA,IHC
CSB-PA599200	TNFSF13 Antibody	Human,Mouse	ELISA,IHC
CSB-PA587516	TNFSF13 Antibody	Human,Mouse	ELISA,IHC

APRIL Proteins

APRIL Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP023989HU CSB-EP023989HU CSB-BP023989HU CSB-EP023989HU-B	Recombinant Human Tumor necrosis factor ligand superfamily member 13 (TNFSF13)	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli