ART1
ART1，全稱為ADP-核糖基轉(zhuǎn)移酶1，是一種位于細(xì)胞表面的膜錨定蛋白，參與蛋白質(zhì)的ADP核糖化修飾。該蛋白在多種生理和病理過程中發(fā)揮作用，包括腫瘤細(xì)胞的增殖、侵襲、凋亡、自噬和血管生成等。ART1蛋白通過與NAD+結(jié)合，催化蛋白質(zhì)中的精氨酸殘基進(jìn)行ADP核糖化，從而調(diào)節(jié)蛋白質(zhì)的功能和活性。研究表明，ART1蛋白在腫瘤發(fā)生發(fā)展中起著重要作用，其高表達(dá)與腫瘤細(xì)胞的免疫逃逸和耐藥性相關(guān)。因此，ART1蛋白成為近年來腫瘤免疫治療研究的熱點(diǎn)靶點(diǎn)。目前，針對(duì)ART1蛋白的藥物研發(fā)尚處于早期階段，主要集中于抗體藥物的開發(fā)。例如，研究人員已成功開發(fā)出一種能特異性抑制ART1蛋白活性的抗體，并在動(dòng)物實(shí)驗(yàn)中顯示出良好的抗腫瘤效果。此外，ART1蛋白還與糖尿病等疾病相關(guān)，其在疾病發(fā)生發(fā)展中的作用機(jī)制和臨床應(yīng)用價(jià)值有待進(jìn)一步研究。
熱銷產(chǎn)品
Recombinant Human GPI-linked NAD (P) (+)--arginine ADP-ribosyltransferase 1 (ART1) (CSB-YP002155HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Western blot analysis of MOUSE-BRAIN lysis using ART1 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
Western Blot analysis of various cells using Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000
ART1 Antibodies
ART1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA302605 | ART1 Antibody | Human | WB, ELISA |
| CSB-PA002155LA01HU | ART1 Antibody | Human | ELISA, IHC |
ART1 Proteins
ART1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002155HU | Recombinant Human GPI-linked NAD (P) (+)--arginine ADP-ribosyltransferase 1 (ART1) | Yeast |
| CSB-EP002155HU | Recombinant Human GPI-linked NAD (P) (+)--arginine ADP-ribosyltransferase 1 | E.coli |
| CSB-BP002155HU CSB-MP002155HU CSB-EP002155HU-B |
Recombinant Human GPI-linked NAD (P) (+)--arginine ADP-ribosyltransferase 1 (ART1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002155HUb0 | Recombinant Human GPI-linked NAD (P) (+)--arginine ADP-ribosyltransferase 1 (ART1) | E.coli |
