BACH1
BACH1，全稱為BTB and CNC homolog 1，常見別名為BRIP1、OF、FANCJ。該蛋白屬于亮氨酸拉鏈家族，具有與血紅素結(jié)合的能力，在維持血紅素對(duì)氧化應(yīng)激的穩(wěn)態(tài)反應(yīng)方面發(fā)揮重要作用。BACH1與核轉(zhuǎn)錄因子紅系2相關(guān)因子2（NRF2）競(jìng)爭與氧化應(yīng)激反應(yīng)基因中的抗氧化反應(yīng)元件結(jié)合，從而影響氧化應(yīng)激反應(yīng)基因的表達(dá)。BACH1蛋白的異常可能與范科尼貧血（FA）等疾病相關(guān)，該病是一種罕見的遺傳性血液疾病，患者缺乏有效的DNA修復(fù)功能。
近年來，針對(duì)BACH1蛋白的藥物研發(fā)取得了一定進(jìn)展。例如，安斯泰來公司研發(fā)的ASP-8731通過抑制BACH1蛋白，增加抗氧化劑和HbF基因的表達(dá)，預(yù)防或減少疾病進(jìn)展。此外，IMMvention Therapeutix公司與諾和諾德合作，共同開發(fā)用于治療鐮狀細(xì)胞病等疾病的口服BACH1抑制劑。這些研究為BACH1相關(guān)疾病的治療提供了新的策略和希望。
熱銷產(chǎn)品
Recombinant Human Transcription regulator protein BACH1 (BACH1) (CSB-EP002526HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BACH1 Antibody (CSB-PA002526ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: BACH1 antibody at 2μg/ml + Mouse thymus tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 82 kDa
Observed band size: 82 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA002526ESR1HU at dilution of 1:100
BACH1 Antibodies
BACH1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002526GA01HU | BACH1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA002526ESR2HU | BACH1 Antibody | Human | ELISA, IHC |
| CSB-PA002526ESR1HU | BACH1 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA000965 | BACH1 Antibody | Human | WB, IHC, IF, ELISA |
BACH1 Proteins
BACH1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002526MO CSB-BP002526MO CSB-MP002526MO |
Recombinant Mouse Transcription regulator protein BACH1 (Bach1) | Yeast Baculovirus Mammalian cell |
BACH1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002526HU CSB-BP002526HU CSB-MP002526HU CSB-EP002526HU-B |
Recombinant Human Transcription regulator protein BACH1 (BACH1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002526HU | Recombinant Human Transcription regulator protein BACH1 (BACH1) | E.coli |
