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BRD4

BRD4,即溴結(jié)構(gòu)域蛋白4,別名BRD4。BRD4是一種屬于溴結(jié)構(gòu)域和超末端結(jié)構(gòu)域(BET)家族的蛋白,主要通過(guò)識(shí)別乙?;M蛋白來(lái)調(diào)節(jié)基因表達(dá)。BRD4的作用機(jī)制主要涉及其與轉(zhuǎn)錄因子的相互作用。BRD4通過(guò)其兩個(gè)溴結(jié)構(gòu)域(BD1和BD2)結(jié)合乙酰化的組蛋白,定位于目標(biāo)基因的啟動(dòng)子或增強(qiáng)子區(qū)域,促進(jìn)相關(guān)基因的轉(zhuǎn)錄。此外,BRD4還通過(guò)招募轉(zhuǎn)錄延伸因子和其他調(diào)節(jié)因子,增強(qiáng)RNA聚合酶II的活性,從而促進(jìn)基因的轉(zhuǎn)錄伸長(zhǎng)。BRD4在細(xì)胞周期、增殖和凋亡等生理過(guò)程中起著關(guān)鍵作用。研究表明,BRD4的異常表達(dá)與多種惡性腫瘤的發(fā)生發(fā)展相關(guān),包括急性髓系白血病、多發(fā)性骨髓瘤、乳腺癌和膠質(zhì)母細(xì)胞瘤等。BRD4不僅參與腫瘤細(xì)胞的增殖和轉(zhuǎn)移,還在DNA損傷修復(fù)和端粒維持中發(fā)揮重要作用。因此,BRD4成為了癌癥治療的一個(gè)重要靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Bromodomain-containing protein 4 (BRD4), partial (CSB-EP002802HU)

驗(yàn)證數(shù)據(jù)

CSB-EP002802HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BRD4 Recombinant Monoclonal Antibody (CSB-RA152430A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA152430A0HU

Western Blot
Positive WB detected in: Hela whole cell lysate, 293T whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: BRD4 antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 153, 81, 89 kDa
Observed band size: 153 kDa

CSB-RA152430A0HU

IHC image of CSB-RA152430A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA152430A0HU

IHC image of CSB-RA152430A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

BRD4 Antibodies

BRD4 for Homo sapiens (Human)

BRD4 Proteins

BRD4 Proteins for Homo sapiens (Human)

BRD4 Proteins for Mus musculus (Mouse)

BRD4 ELISA Kit

BRD4 ELISA Kit for Homo sapiens (Human)