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BTK

BTK,即布魯頓酪氨酸激酶,別名AGMX1 ATK BPK。它是一種非受體酪氨酸激酶,屬于Tec激酶家族成員,在所有造血細胞中廣泛存在,除了T細胞和漿細胞。BTK的作用機制主要是通過參與B細胞受體(BCR)信號通路,傳遞BCR接受到的信號并調控B細胞的增殖和存活。BTK包含5個結構域:PH結構域、TH結構域、SH3結構域、SH2結構域和SH1/TK催化結構域,這些結構域可以識別并結合多種信號分子 。BTK在生物學上的意義非常廣泛,它不僅參與了B細胞的成熟、存活、分化、凋亡、遷移等過程,還涉及了多種疾病的發生發展,尤其是在B細胞淋巴瘤中,BTK是BCR信號通路中的關鍵激酶。BTK抑制劑可以與BTK活性中心的半胱氨酸殘基共價結合,從而抑制其活性,進而抑制BCR信號通路的激活,有效阻止腫瘤從B細胞遷移至適宜腫瘤生長的淋巴組織,減少B細胞惡性增殖并誘導細胞的凋亡,從而發揮治療作用 。

熱銷產品

Recombinant Human Tyrosine-protein kinase BTK (BTK) (CSB-BP002867HU(A4))

驗證數據

CSB-BP002867HU(A4)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BTK Recombinant Monoclonal Antibody (CSB-RA553167A0HU)

驗證數據

CSB-RA553167A0HU

IHC image of CSB-RA553167A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

BTK Antibodies

BTK for Homo sapiens (Human)

BTK Proteins

BTK Proteins for Mus musculus (Mouse)

BTK Proteins for Gallus gallus (Chicken)

BTK Proteins for Homo sapiens (Human)