CCND1
CCND1，即細(xì)胞周期蛋白D1，別名包括BCL1、PRAD1、U21B31、D11S287E。CCND1由人類CCND1基因編碼，該基因位于11號(hào)染色體的q13.3區(qū)域。CCND1是細(xì)胞周期中的關(guān)鍵調(diào)節(jié)因子，其編碼的蛋白質(zhì)屬于高度保守的細(xì)胞周期蛋白家族，這些蛋白在細(xì)胞周期中的豐度具有顯著周期性。CCND1與CDK4或CDK6形成復(fù)合物并作為其調(diào)節(jié)亞基，其活性對(duì)于細(xì)胞周期G1/S過渡是必需的。CCND1與腫瘤抑制蛋白R(shí)b相互作用，并且這個(gè)基因的表達(dá)受到Rb的正向調(diào)控。CCND1的突變、擴(kuò)增和過度表達(dá)會(huì)改變細(xì)胞周期的進(jìn)程，這在多種人類癌癥中經(jīng)常觀察到。CCND1在細(xì)胞增殖、分化和凋亡過程中起著關(guān)鍵作用，其異常表達(dá)與腫瘤的發(fā)生、發(fā)展密切相關(guān)，是多種癌癥治療的重要靶點(diǎn)。
熱銷產(chǎn)品
CCND1 Recombinant Monoclonal Antibody (CSB-RA616025A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate, SH-SY5Y whole cell lysate, U-87 whole cell lysate
All lanes: Cyclin D1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 34 kDa
Observed band size: 34 kDa
CCND1 Antibodies
CCND1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004811LD01HU | CCND1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA004811LC01HU | CCND1 Antibody, FITC conjugated | Human | |
| CSB-PA004811LB01HU | CCND1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004811LA01HU | CCND1 Antibody | Human | ELISA |
| CSB-PA004811KA01HU | CCND1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,ICC,IP |
| CSB-PA184970 | Phospho-CCND1 (Thr286) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA963558 | Phospho-CCND1 (Ser90) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000642 | Phospho-CCND1 (T286) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA001875 | CCND1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA040188 | CCND1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA080258 | CCND1 Antibody | Rat,Mouse | WB, IHC |
| CSB-PA516472 | CCND1 Antibody | Human | ELISA,IHC |
| CSB-PA446984 | CCND1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA843257 | CCND1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA616025A0HU | CCND1 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB |
CCND1 Proteins
CCND1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004811HU CSB-BP004811HU CSB-MP004811HU |
Recombinant Human G1/S-specific cyclin-D1 (CCND1) | Yeast Baculovirus Mammalian cell |
| CSB-EP004811HU | Recombinant Human G1/S-specific cyclin-D1 (CCND1) | E.coli |
| CSB-EP004811HU-B | Recombinant Human G1/S-specific cyclin-D1 (CCND1), Biotinylated | E.coli |
CCND1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004811MO CSB-EP004811MO CSB-BP004811MO CSB-MP004811MO CSB-EP004811MO-B |
Recombinant Mouse G1/S-specific cyclin-D1 (Ccnd1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004811RA CSB-EP004811RA CSB-BP004811RA CSB-MP004811RA CSB-EP004811RA-B |
Recombinant Rat G1/S-specific cyclin-D1 (Ccnd1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004811CH CSB-EP004811CH CSB-BP004811CH CSB-MP004811CH CSB-EP004811CH-B |
Recombinant Chicken G1/S-specific cyclin-D1 (CCND1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004811XBE CSB-EP004811XBE CSB-BP004811XBE CSB-MP004811XBE CSB-EP004811XBE-B |
Recombinant Xenopus laevis G1/S-specific cyclin-D1 (ccnd1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP645607BO CSB-EP645607BO CSB-BP645607BO CSB-MP645607BO CSB-EP645607BO-B |
Recombinant Bovine G1/S-specific cyclin-D1 (CCND1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND1 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP728931PYX CSB-EP728931PYX CSB-BP728931PYX CSB-MP728931PYX CSB-EP728931PYX-B |
Recombinant Pongo abelii G1/S-specific cyclin-D1 (CCND1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP731088DO CSB-EP731088DO CSB-BP731088DO CSB-MP731088DO CSB-EP731088DO-B |
Recombinant Dog G1/S-specific cyclin-D1 (CCND1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCND1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP820871DIL CSB-EP820871DIL CSB-BP820871DIL CSB-MP820871DIL CSB-EP820871DIL-B |
Recombinant Danio rerio G1/S-specific cyclin-D1 (ccnd1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
