CD200
CD200，全名為OX-2膜糖蛋白，是一種廣泛表達的免疫調(diào)節(jié)分子，常見別名包括MOX1、MOX2、MRC、OX-2和My033。該蛋白屬于免疫球蛋白超家族，含有兩個免疫球蛋白結構域，主要在多種細胞類型上表達，如巨噬細胞、樹突狀細胞和血管內(nèi)皮細胞等。CD200通過與CD200受體（CD200R）結合，在調(diào)節(jié)免疫反應中發(fā)揮重要作用，例如抑制巨噬細胞和嗜酸性粒細胞的功能，從而減輕炎癥反應。此外，CD200還與多種疾病相關，包括移植排斥反應、自身免疫性疾病（如類風濕關節(jié)炎和系統(tǒng)性紅斑狼瘡）以及某些血液系統(tǒng)惡性腫瘤（如慢性淋巴細胞白血病和多發(fā)性骨髓瘤）。在藥物研發(fā)方面，CD200及其受體已成為潛在的免疫治療靶點，相關研究主要集中在開發(fā)針對CD200/CD200R信號通路的抑制劑，以調(diào)節(jié)免疫反應，治療自身免疫性疾病和腫瘤。例如，有研究表明，CD200過表達的移植模型可建立“耐受”狀態(tài)，而CD200持續(xù)存在可抑制排斥反應。此外，阻斷CD200/CD200R信號通路可降低腫瘤微環(huán)境中的免疫抑制，從而抑制腫瘤生長。
熱銷產(chǎn)品
Recombinant Human OX-2 membrane glycoprotein (CD200), partial (CSB-EP004895HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CD200 Antibody (CSB-PA004895ESR2HU)
驗證數(shù)據(jù)
Western blot
All lanes: CD200antibody at 0.71μg/ml + Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 32, 31, 33 kDa
Observed band size: 32 kDa
CD200 Antibodies
CD200 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005858 | CD200 Antibody | Human | WB, ELISA |
| CSB-PA004895ESR1HU | CD200 Antibody | Human | ELISA, IHC |
| CSB-PA004895ESR2HU | CD200 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA004895EA01HU | CD200 Antibody | Human | ELISA, IF |
| CSB-PA004895EC01HU | CD200 Antibody, FITC conjugated | Human | |
| CSB-PA004895ED01HU | CD200 Antibody, Biotin conjugated | Human | ELISA |
CD200 Proteins
CD200 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004895HU1 CSB-BP004895HU1 CSB-EP004895HU1-B |
Recombinant Human OX-2 membrane glycoprotein (CD200), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF004895HU | Recombinant Human OX-2 membrane glycoprotein (CD200) | in vitro E.coli expression system |
| CSB-EP004895HU1 | Recombinant Human OX-2 membrane glycoprotein (CD200), partial | E.coli |
CD200 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004895RA1 CSB-EP004895RA1 CSB-BP004895RA1 CSB-MP004895RA1 CSB-EP004895RA1-B |
Recombinant Rat OX-2 membrane glycoprotein (Cd200), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004895RA | Recombinant Rat OX-2 membrane glycoprotein (Cd200) | in vitro E.coli expression system |
CD200 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004895MO1 CSB-BP004895MO1 CSB-MP004895MO1 |
Recombinant Mouse OX-2 membrane glycoprotein (Cd200), partial | Yeast Baculovirus Mammalian cell |
| CSB-CF004895MO | Recombinant Mouse OX-2 membrane glycoprotein (Cd200) | in vitro E.coli expression system |
CD200 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP722381PYX CSB-EP722381PYX CSB-BP722381PYX CSB-MP722381PYX CSB-EP722381PYX-B |
Recombinant Pongo abelii OX-2 membrane glycoprotein (CD200), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD200 ELISA Kit
CD200 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL004895RA | Rat OX-2 membrane glycoprotein(CD200) ELISA kit | serum, plasma, tissue homogenates | 11.75 pg/mL |
