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CD247

CD247,全名為CD3 zeta/CD247蛋白,也被稱為T細(xì)胞表面糖蛋白CD3 zeta鏈、CD247、CD3Z、T3Z、TCRZ。它是T淋巴細(xì)胞表面TCR-CD3復(fù)合物的組成部分,對(duì)于適應(yīng)性免疫反應(yīng)至關(guān)重要。CD247蛋白在免疫反應(yīng)中起到傳遞信號(hào)的作用,能夠激活T細(xì)胞,從而啟動(dòng)免疫反應(yīng)。此外,CD247蛋白與多種蛋白質(zhì)相互作用,有助于其在免疫反應(yīng)和細(xì)胞相互作用中發(fā)揮多方面的功能。在腫瘤和自身免疫性疾病的研究中,CD247蛋白的表達(dá)和功能改變與T淋巴細(xì)胞異常活化相關(guān),成為研究的熱點(diǎn)。目前,針對(duì)CD247蛋白的藥物研發(fā)正在取得進(jìn)展,有望為腫瘤和自身免疫性疾病的治療帶來新的突破。

熱銷產(chǎn)品

CD247 Recombinant Monoclonal Antibody (CSB-RA244537A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA244537A0HU

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

CD247 Antibody (CSB-PA10499A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA10499A0Rb

Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: CD247 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 19 kDa
Observed band size: 19 kDa

CSB-PA10499A0Rb

Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA10499A0Rb at dilution of 1:100

CSB-PA10499A0Rb

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA10499A0Rb at dilution of 1:100

CSB-PA10499A0Rb

Immunofluorescent analysis of HepG2 cells using CSB-PA10499A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CSB-PA10499A0Rb

Immunoprecipitating CD247 in jurkat whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-PA10499A0Rb in jurkat whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA10499A0Rb (8µg) + jurkat whole cell lysate (500µg)
Lane 3: Jurkat whole cell lysate (10µg)

Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit (CSB-EL004904HU)

驗(yàn)證數(shù)據(jù)

CSB-EL004904HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL004904HU

規(guī)格:96T/48T

靈敏度:0.039 ng/mL

檢測(cè)范圍:0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CD247 Antibodies

CD247 for Homo sapiens (Human)

CD247 Proteins

CD247 Proteins for Homo sapiens (Human)

CD247 Proteins for Ovis aries (Sheep)

CD247 Proteins for Mus musculus (Mouse)

CD247 Proteins for Oryctolagus cuniculus (Rabbit)

CD247 Proteins for Sus scrofa (Pig)

CD247 ELISA Kit

CD247 ELISA Kit for Homo sapiens (Human)