CD28

CD28全稱為分化簇28抗原，是T細胞表面關鍵的共刺激受體，其晶體結構呈現典型的免疫球蛋白樣二聚體構型。該蛋白通過與抗原呈遞細胞表面的B7分子（CD80/CD86）結合，為T細胞活化提供第二信號，這種雙信號機制決定了免疫應答的特異性與強度。在腫瘤微環境中，CD28信號缺失常導致T細胞耗竭，而過度激活則與類風濕性關節炎、系統性紅斑狼瘡等自身免疫疾病密切相關。目前全球已上市藥物阿巴西普通過競爭性結合B7分子間接調控CD28通路，用于中重度類風濕治療。在CAR-T細胞治療領域，第二代產品普遍采用CD28或4-1BB作為共刺激結構域，顯著提升了抗腫瘤活性。近年來針對CD28的新型雙特異性抗體進入臨床，既可阻斷病理性的過度激活，又能定向增強抗腫瘤免疫，這種雙向調節策略為免疫相關疾病的精準干預開辟了新路徑。

熱銷產品

Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial (CSB-MP004913HU1)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

The purity of CD28 was greater than 95% as determined by SEC-HPLC

CD28 Antibody (CSB-PA005199)

驗證數據

Western Blot analysis of K562 cells using CD28 Polyclonal Antibody

Human soluble cluster of differentiation 28,sCD28 ELISA Kit (CSB-E09296h)

驗證數據

貨號：CSB-E09296h

規格：96T/48T

靈敏度：0.156 ng/mL

檢測范圍：0.625 ng/mL-40 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CD28 Antibody

CD28 Protein

CD28 ELISA Kit

CD28 Antibodies

CD28 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA005199	CD28 Antibody	Human	WB, ELISA
CSB-PA070302	Phospho-CD28 (Y218) Antibody	Human,Mouse	WB, ELISA

CD28 Proteins

CD28 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP004913HU1 CSB-EP004913HU1 CSB-BP004913HU1 CSB-EP004913HU1-B	Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-CF004913HU	Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28)	in vitro E.coli expression system
CSB-MP004913HU1	Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial	Mammalian cell

CD28 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP004913MO1 CSB-EP004913MO1 CSB-BP004913MO1 CSB-MP004913MO1 CSB-EP004913MO1-B	Recombinant Mouse T-cell-specific surface glycoprotein CD28 (Cd28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004913MO	Recombinant Mouse T-cell-specific surface glycoprotein CD28 (Cd28)	in vitro E.coli expression system

CD28 Proteins for Oryctolagus cuniculus (Rabbit)

產品貨號	產品名稱	來源
CSB-YP004913RB1 CSB-EP004913RB1 CSB-BP004913RB1 CSB-MP004913RB1 CSB-EP004913RB1-B	Recombinant Rabbit T-cell-specific surface glycoprotein CD28 (CD28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004913RB	Recombinant Rabbit T-cell-specific surface glycoprotein CD28 (CD28)	in vitro E.coli expression system

CD28 Proteins for Gallus gallus (Chicken)

產品貨號	產品名稱	來源
CSB-YP004913CH1 CSB-EP004913CH1 CSB-BP004913CH1 CSB-MP004913CH1 CSB-EP004913CH1-B	Recombinant Chicken T-cell-specific surface glycoprotein CD28 homolog (CD28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004913CH	Recombinant Chicken T-cell-specific surface glycoprotein CD28 homolog (CD28)	in vitro E.coli expression system

CD28 Proteins for Felis catus (Cat) (Felis silvestris catus)

產品貨號	產品名稱	來源
CSB-YP004913CA1 CSB-EP004913CA1 CSB-BP004913CA1 CSB-MP004913CA1 CSB-EP004913CA1-B	Recombinant Cat T-cell-specific surface glycoprotein CD28 (CD28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004913CA	Recombinant Cat T-cell-specific surface glycoprotein CD28 (CD28)	in vitro E.coli expression system

CD28 Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP004913RA1 CSB-EP004913RA1 CSB-BP004913RA1 CSB-MP004913RA1 CSB-EP004913RA1-B	Recombinant Rat T-cell-specific surface glycoprotein CD28 (Cd28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004913RA	Recombinant Rat T-cell-specific surface glycoprotein CD28 (Cd28)	in vitro E.coli expression system

CD28 Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP638916BO CSB-EP638916BO CSB-BP638916BO CSB-MP638916BO CSB-EP638916BO-B	Recombinant Bovine T-cell-specific surface glycoprotein CD28 (CD28), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli