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CHD1

ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity).

CHD1 Antibodies

CHD1 for Homo sapiens (Human)

CHD1 Proteins

CHD1 Proteins for Mus musculus (Mouse)

CHD1 Proteins for Gallus gallus (Chicken)

CHD1 Proteins for Homo sapiens (Human)

CHD1 Proteins for Bombyx mori (Silk moth)

CHD1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

CHD1 Proteins for Drosophila melanogaster (Fruit fly)