CLIC1
CLIC1，全稱為氯離子細(xì)胞內(nèi)通道蛋白1，是一種具有多種功能的蛋白質(zhì)。它也被稱為MCLC（Mid1-related chloride channel），屬于CLIC家族，該家族的成員通常具有雙重功能，既可作為可溶性蛋白存在于細(xì)胞質(zhì)中，也可插入細(xì)胞膜形成離子通道。CLIC1主要在細(xì)胞內(nèi)質(zhì)網(wǎng)中表達(dá)，對維持內(nèi)質(zhì)網(wǎng)穩(wěn)態(tài)至關(guān)重要，其功能涉及調(diào)節(jié)內(nèi)質(zhì)網(wǎng)相關(guān)的鈣離子信號傳導(dǎo)和未折疊蛋白反應(yīng)，從而影響蛋白質(zhì)的正確折疊與降解。CLIC1的突變或功能異常與多種疾病相關(guān)，例如，研究發(fā)現(xiàn)CLIC1的某些突變可能導(dǎo)致內(nèi)質(zhì)網(wǎng)應(yīng)激反應(yīng)失調(diào)，進(jìn)而引發(fā)神經(jīng)退行性疾病，如視網(wǎng)膜色素變性（retinitis pigmentosa）和肌萎縮側(cè)索硬化癥（ALS）。此外，CLIC1的表達(dá)異常還與某些癌癥的發(fā)展相關(guān)，可能通過影響細(xì)胞凋亡或增殖信號通路發(fā)揮作用。目前，CLIC1作為外源性抗氧化劑的潛力正在被研究，其在皮膚抗衰老、炎癥性疾病及氧化應(yīng)激相關(guān)病癥的防治中具有重要意義。
熱銷產(chǎn)品
CLIC1 Antibody (CSB-PA005545ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Chloride intracellular channel protein 1 antibody at 4μg/ml
Lane 1: Hela whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 27 kDa
Observed band size: 27 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA005545ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA005545ESR1HU at dilution of 1:100
CLIC1 Antibodies
CLIC1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005545GA01HU | CLIC1 Antibody | Human,Mouse,Rat | ELISA,IHC,IF |
| CSB-PA005545ESR1HU | CLIC1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA347049 | CLIC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CLIC1 Proteins
CLIC1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005545HU1 CSB-EP005545HU1 CSB-BP005545HU1 CSB-MP005545HU1 CSB-EP005545HU1-B |
Recombinant Human Chloride intracellular channel protein 1 (CLIC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005545HU | Recombinant Human Chloride intracellular channel protein 1 (CLIC1) | in vitro E.coli expression system |
