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Cd40l

CD40L,全稱為CD40配體(CD154),是一種II型跨膜蛋白,主要由活化的CD4+ T淋巴細胞表達。它通過與廣泛表達的CD40受體結合,在B細胞的活化、分化、成熟和凋亡中發揮關鍵作用。CD40L還參與免疫反應的調節和維持,例如在生發中心反應中促進抗體類別轉換,以及通過激活樹突細胞分泌IL-12,推動Th1型免疫應答。此外,CD40L還與多種整合素結合,參與炎癥反應和細胞因子分泌。CD40L的表達異常與高IgM綜合征等疾病相關。目前,針對CD40L的藥物研發主要集中在自身免疫性疾病和腫瘤領域,例如CD40L激動劑和拮抗劑,以及新型分子治療策略。一些CD40L拮抗劑已進入臨床試驗,并在系統性紅斑狼瘡、多發性硬化癥等疾病中顯示出療效。

熱銷產品

Recombinant Human CD40 ligand (CD40LG), partial (Active) (CSB-MP004937HU3)

驗證數據

CSB-MP004937HU3

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP004937HU3

Activity
Measured by its binding ability in a functional ELISA. Immobilized CD40L at 2 μg/ml can bind Anti- CD40L Rabbit Monoclonal Antibody(CSB-RA156386A0HU), the EC50 is 2.353-3.232 ng/ml.

CSB-MP004937HU3

Activity
Measured by its binding ability in a functional ELISA. Immobilized CD40(CSB-MP004936HU1) at 2 μg/ml can bind CD40L, the EC50 is 3.112-3.858 ng/ml.

CSB-MP004937HU3

Activity
Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.

Recombinant Human CD40 ligand (CD40LG), partial (CSB-EP004937HU1a0)

驗證數據

CSB-EP004937HU1a0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit (CSB-E04716h)

驗證數據

CSB-E04716h 標準曲線

貨號:CSB-E04716h

規格:96T/48T

靈敏度:0.078 ng/mL

檢測范圍:0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Cd40l Antibodies

Cd40l for Homo sapiens (Human)

Cd40l Proteins

Cd40l Proteins for Homo sapiens (Human)

Cd40l ELISA Kit

Cd40l ELISA Kit for Homo sapiens (Human)