DLL4

DLL4，全稱為Delta-like protein 4，也被稱為δ樣蛋白-4，在血管生成與重塑中發(fā)揮著核心作用。DLL4的異常表達(dá)與多種病理狀態(tài)下的血管異常生成密切相關(guān)，如腫瘤、視網(wǎng)膜病變及心血管疾病等。研究表明，DLL4不僅是血管生成的重要調(diào)控因子，其異常調(diào)控還可能通過影響內(nèi)皮細(xì)胞行為參與疾病進(jìn)展，因此成為近年來疾病治療的研究熱點(diǎn)。
DLL4的高表達(dá)與多種腫瘤如結(jié)直腸癌、肺癌、肝癌等密切相關(guān)，通過激活Notch信號通路，DLL4能夠抑制正常的血管生成，形成異常的血管網(wǎng)絡(luò)，為腫瘤的生長和轉(zhuǎn)移提供有利條件。DLL4還與視網(wǎng)膜病變、心血管疾病、慢性腎病、肌肉萎縮與代謝性疾病、遺傳性血管疾病等多種疾病相關(guān)。
目前，抗DLL4抗體可抑制腫瘤血管生成，但長期使用可能誘發(fā)肝血管肉瘤等毒性，因此，研究人員正在探索DLL4與其他藥物的聯(lián)合應(yīng)用，以增強(qiáng)抗腫瘤效果并降低耐藥風(fēng)險(xiǎn)。目前已有2條DLL4 x VEGF雙抗管線在研，最高研究階段處于臨床2/3期，為腫瘤治療提供了新的希望。

熱銷產(chǎn)品

Recombinant Human Delta-like protein 4 (DLL4), partial (Active) (CSB-MP878862HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human DLL4 at 2 μg/ml can bind Anti-DLL4 recombinant antibody (CSB-RA878862MA1HU). The EC₅₀ is 2.322-2.607 ng/mL.

DLL4 (Navicixizumab) Recombinant Monoclonal Antibody (CSB-RA878862MA1HU)

驗(yàn)證數(shù)據(jù)

The Binding Activity of Human DLL4 with Anti-DLL4 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DLL4 (CSB-MP878862HU) at 2 μg/mL can bind Anti-DLL4 recombinant antibody . The EC₅₀ is 2.322-2.607 ng/mL.

DLL4 Antibody (CSB-PA006949LA01HU)

驗(yàn)證數(shù)據(jù)

Immunofluorescent analysis of MCF-7 cells using CSB-PA006949LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human Delta-like protein 4(DLL4) ELISA kit (CSB-EL006949HU)

驗(yàn)證數(shù)據(jù)

貨號：CSB-EL006949HU

規(guī)格：96T/48T

靈敏度：5.8 pg/mL

檢測范圍：23.5 pg/mL-1500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

DLL4 Antibody

DLL4 Protein

DLL4 ELISA Kit

DLL4 Antibodies

DLL4 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA073786	DLL4 Antibody	Human,Mouse	ELISA,IHC
CSB-PA831848	DLL4 Antibody	Human,Mouse	ELISA,IHC
CSB-PA006949LA01HU	DLL4 Antibody	Human	ELISA, IF
CSB-PA006949LB01HU	DLL4 Antibody, HRP conjugated	Human	ELISA
CSB-PA006949LC01HU	DLL4 Antibody, FITC conjugated	Human
CSB-PA006949LD01HU	DLL4 Antibody, Biotin conjugated	Human	ELISA
CSB-RA878862MA1HU	DLL4 (Navicixizumab) Recombinant Monoclonal Antibody	Human	ELISA

DLL4 Proteins

DLL4 Proteins for Xenopus laevis (African clawed frog)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP347231XBE CSB-EP347231XBE CSB-BP347231XBE CSB-MP347231XBE CSB-EP347231XBE-B	Recombinant Xenopus laevis Homeobox protein DLL-4 (dll4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DLL4 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP867483MO CSB-EP867483MO CSB-BP867483MO CSB-MP867483MO CSB-EP867483MO-B	Recombinant Mouse Delta-like protein 4 (Dll4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DLL4 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP878862HU CSB-EP878862HU CSB-BP878862HU CSB-EP878862HU-B	Recombinant Human Delta-like protein 4 (DLL4), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP878862HU	Recombinant Human Delta-like protein 4 (DLL4), partial (Active)	Mammalian cell