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FGFR3

FGFR3,全稱為成纖維細(xì)胞生長因子受體3,別名包括ACH、CD333、CEK2等。該蛋白通過激活下游信號通路,如PI3K/AKT、MAPK/ERK、STAT等,參與調(diào)控細(xì)胞生長和存活。FGFR3蛋白的過表達(dá)或突變可導(dǎo)致信號傳導(dǎo)異常,從而促進(jìn)腫瘤細(xì)胞的增殖和存活。
FGFR3蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān),其中包括多發(fā)性骨髓瘤、尿路上皮癌、骨肉瘤等。研究表明,F(xiàn)GFR3蛋白的表達(dá)水平或突變狀態(tài)可作為這些疾病的診斷、預(yù)后評估和治療方案選擇的參考指標(biāo)。
針對FGFR3蛋白的靶向治療藥物研發(fā)已取得顯著進(jìn)展。例如,TYRA-300是一種口服選擇性FGFR3抑制劑,在治療FGFR3突變轉(zhuǎn)移性尿路上皮癌患者中表現(xiàn)出優(yōu)異的療效和良好的安全性。此外,還有多種FGFR3靶向抗體偶聯(lián)藥物、酪氨酸激酶抑制劑等藥物正在臨床前研究和臨床試驗中,有望為FGFR3相關(guān)疾病患者提供新的治療選擇。

熱銷產(chǎn)品

Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (Active) (CSB-MP008646HU)

驗證數(shù)據(jù)

CSB-MP008646HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP008646HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FGFR3 at 2 μg/ml can bind Anti-FGFR3 recombinant antibody (CSB-RA008646MA1HU). The EC50 is 0.6767-0.8946 ng/mL.

CSB-MP008646HU

The purity of FGFR3 was greater than 95% as determined by SEC-HPLC

Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (Active) (CSB-MP008646HU(F2))

驗證數(shù)據(jù)

CSB-MP008646HU(F2)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP008646HU(F2)

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FGFR3 at 2 μg/ml can bind Anti-FGFR3 recombinant antibody (CSB-RA008646MA1HU). The EC50 is 3.364-3.827 ng/mL.

CSB-MP008646HU(F2)

The purity of FGFR3 was greater than 95% as determined by SEC-HPLC

Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (Active) (CSB-MP008646HU1(F2))

驗證數(shù)據(jù)

CSB-MP008646HU1(F2)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP008646HU1(F2)

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FGFR3 at 2 μg/ml can bind Anti-FGFR3 recombinant antibody (CSB-RA008646MA1HU). The EC50 is 0.7264-1.525 ng/mL.

FGFR3 Antibody (CSB-PA008646LA01HU)

驗證數(shù)據(jù)

CSB-PA008646LA01HU

IHC image of CSB-PA008646LA01HU diluted at 1:450 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA008646LA01HU

IHC image of CSB-PA008646LA01HU diluted at 1:450 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA008646LA01HU

Immunofluorescence staining of Hela cells with CSB-PA008646LA01HU at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

FGFR3 Antibodies

FGFR3 for Homo sapiens (Human)

FGFR3 Proteins

FGFR3 Proteins for Gallus gallus (Chicken)

FGFR3 Proteins for Homo sapiens (Human)

FGFR3 Proteins for Xenopus laevis (African clawed frog)

FGFR3 Proteins for Mus musculus (Mouse)

FGFR3 Proteins for Pleurodeles waltl (Iberian ribbed newt)

FGFR3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

FGFR3 ELISA Kit

FGFR3 ELISA Kit for Homo sapiens (Human)