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Your Good Partner in Biology Research

FYN

FYN全稱為酪氨酸蛋白激酶Fyn,屬于Src家族成員,在細胞信號傳導中發揮核心作用。FYN存在兩種異構體,分別通過不同剪切方式產生p59-Fyn和p58-Fyn,在T細胞受體激活、神經元發育等過程中參與調控。其異常活化與多種惡性腫瘤密切相關,Fyn激酶在乳腺癌、前列腺癌中通過PI3K/AKT通路促進腫瘤轉移,在膠質母細胞瘤中與表皮生長因子受體形成致癌復合物。阿爾茨海默病患者腦組織中發現Fyn與Tau蛋白異常互作,加速神經纖維纏結形成,而帕金森病模型中也觀察到該激酶對α-突觸核蛋白聚集的促進作用。針對Fyn的藥物開發聚焦于激酶抑制劑領域,達沙替尼等廣譜Src抑制劑已進入臨床研究,新型選擇性抑制劑如AZD0424在臨床前實驗中顯示出對三陰性乳腺癌的特異性抑制作用。近期研究還發現Fyn在免疫檢查點調控中的作用,其與PD-1受體的相互作用為腫瘤免疫治療提供了新靶點。

熱銷產品

FYN Recombinant Monoclonal Antibody (CSB-RA699767A0HU)

驗證數據

CSB-RA699767A0HU

IHC image of CSB-RA699767A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA699767A0HU

IHC image of CSB-RA699767A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

FYN Antibodies

FYN for Homo sapiens (Human)

FYN Proteins

FYN Proteins for Mus musculus (Mouse)

FYN Proteins for Homo sapiens (Human)

FYN Proteins for Bos taurus (Bovine)

FYN Proteins for Sus scrofa (Pig)

FYN Proteins for Xenopus laevis (African clawed frog)

FYN Proteins for Xiphophorus helleri (Green swordtail)

FYN Proteins for Rattus norvegicus (Rat)