GNA13
GNA13，全稱為鳥嘌呤核苷酸結(jié)合蛋白α13亞基，常被簡(jiǎn)稱為Gα13。這種蛋白在細(xì)胞信號(hào)傳遞中扮演著重要角色：當(dāng)細(xì)胞表面的特定受體接收到外界信號(hào)時(shí)，它會(huì)被激活，進(jìn)而觸發(fā)下游一系列反應(yīng)，影響細(xì)胞的遷移、增殖和形態(tài)改變——比如幫助細(xì)胞調(diào)整內(nèi)部骨架結(jié)構(gòu)，讓細(xì)胞能夠移動(dòng)到其他位置。
在疾病方面，Gα13的異常與多種病癥相關(guān)：胃癌、乳腺癌等癌癥中，它的表達(dá)量或活性失衡可能促進(jìn)腫瘤細(xì)胞擴(kuò)散轉(zhuǎn)移；同時(shí)，它也參與心血管系統(tǒng)調(diào)節(jié)，若功能異常可能影響血管內(nèi)壁細(xì)胞運(yùn)作，與高血壓、動(dòng)脈粥樣硬化等問題存在關(guān)聯(lián)。藥物研發(fā)上，針對(duì)Gα13的治療探索仍在進(jìn)行，科學(xué)家試圖找到調(diào)控其活性的小分子化合物，或靶向下游路徑的藥物，但多數(shù)還處于實(shí)驗(yàn)室研究階段，尚未進(jìn)入臨床應(yīng)用。
熱銷產(chǎn)品
Recombinant Human Guanine nucleotide-binding protein subunit alpha-13 (GNA13) (CSB-EP618885HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA101118(GNA13 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA101118(GNA13 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-5: A172 cells, 293T cells, mouse kidney tissue, human testis tissue, Human brain malignant glioma tissue, Primary antibody: CSB-PA101118(GNA13 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
GNA13 Antibodies
GNA13 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009585GA01HU | GNA13 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA101118 | GNA13 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA805573 | GNA13 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
GNA13 Proteins
GNA13 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009585MO CSB-EP009585MO CSB-BP009585MO CSB-MP009585MO CSB-EP009585MO-B |
Recombinant Mouse Guanine nucleotide-binding protein subunit alpha-13 (Gna13) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GNA13 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP618885HU CSB-BP618885HU CSB-MP618885HU CSB-EP618885HU-B |
Recombinant Human Guanine nucleotide-binding protein subunit alpha-13 (GNA13) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP618885HU | Recombinant Human Guanine nucleotide-binding protein subunit alpha-13 (GNA13) | E.coli |
