HAT1
HAT1，即組蛋白乙酰轉(zhuǎn)移酶1，別名KAT1。它是一種B型組蛋白乙酰轉(zhuǎn)移酶，由人類基因組編碼，主要在細(xì)胞質(zhì)中發(fā)揮作用。HAT1的作用機(jī)制是通過其催化結(jié)構(gòu)域?qū)⒁阴］o酶A上的乙酰基轉(zhuǎn)移到新合成的組蛋白H4的賴氨酸殘基上，特別是H4K5和H4K12，以及在較小程度上乙酰化組蛋白H2A的K5。這種乙酰化過程對(duì)于新合成DNA鏈的染色質(zhì)組裝至關(guān)重要，影響基因表達(dá)和染色質(zhì)結(jié)構(gòu)。HAT1在調(diào)控細(xì)胞周期進(jìn)程、DNA復(fù)制、修復(fù)以及轉(zhuǎn)錄調(diào)控中發(fā)揮重要作用。HAT1的異常表達(dá)或活性失調(diào)與多種疾病相關(guān)，包括癌癥。HAT1還參與了腫瘤發(fā)生中組蛋白和非組蛋白的琥珀酰化，影響癌細(xì)胞的表觀遺傳調(diào)控和基因表達(dá)。
熱銷產(chǎn)品
HAT1 Antibody (CSB-PA010143ESR2HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: HAT1 antibody at 3µg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: 293T whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 50, 40 kDa
Observed band size: 50 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA010143ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010143ESR2HU at dilution of 1:100
HAT1 Antibodies
HAT1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010143GA01HU | HAT1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010143ESR2HU | HAT1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA928867 | HAT1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA070071 | HAT1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA010143EA01HU | HAT1 Antibody | Human, Rat | ELISA, WB, IF |
HAT1 Proteins
HAT1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010143HU CSB-BP010143HU CSB-MP010143HU CSB-EP010143HU-B |
Recombinant Human Histone acetyltransferase type B catalytic subunit (HAT1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
