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HCN1

HCN1,即超極化激活型環(huán)核苷酸門控通道1,別名If、Ih、HCN1等。它是一種由HCN1基因編碼的膜蛋白,屬于超極化激活型環(huán)核苷酸門控通道家族成員,在心臟和大腦等組織中表達(dá)。HCN1的作用機(jī)制是在細(xì)胞膜超極化時(shí)激活,允許鈉和鉀離子通過(guò),對(duì)心臟節(jié)律和神經(jīng)元興奮性具有調(diào)節(jié)作用。HCN1參與了心臟的自主節(jié)律控制和心臟起搏,同時(shí)在神經(jīng)系統(tǒng)中調(diào)節(jié)神經(jīng)元的發(fā)放頻率和信號(hào)傳遞。HCN1的功能異常與心臟疾病中的竇性心動(dòng)過(guò)緩、長(zhǎng)QT綜合征,以及神經(jīng)系統(tǒng)疾病中的癲癇有關(guān),是心臟學(xué)和神經(jīng)生物學(xué)研究中的一個(gè)重要分子靶點(diǎn)。

熱銷產(chǎn)品

HCN1 Antibody (CSB-PA010216LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA010216LA01HU

IHC image of CSB-PA010216LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA010216LA01HU

IHC image of CSB-PA010216LA01HU diluted at 1:500 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA010216LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA010216LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

HCN1 Antibodies

HCN1 for Homo sapiens (Human)

HCN1 Proteins

HCN1 Proteins for Homo sapiens (Human)