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IDUA

IDUA(Iduronidase)是一種屬于糖苷水解酶家族的溶酶體酶,其結(jié)構(gòu)復(fù)雜,包含多個(gè)催化位點(diǎn)和底物結(jié)合位點(diǎn),能夠識(shí)別和分解硫酸艾杜糖醛酸,這是黏多糖代謝中的關(guān)鍵步驟。IDUA的主要功能是催化硫酸艾杜糖醛酸的水解,維持細(xì)胞外基質(zhì)的穩(wěn)態(tài)和正常生理功能。盡管IDUA不直接參與信號(hào)轉(zhuǎn)導(dǎo),但它在黏多糖代謝中的作用可能間接影響某些信號(hào)通路,如通過(guò)影響細(xì)胞表面的受體與配體相互作用以及細(xì)胞間相互作用來(lái)改變細(xì)胞對(duì)外部刺激的響應(yīng)。IDUA的缺乏會(huì)導(dǎo)致黏多糖累積病,如粘多糖貯積癥I型(Hurler綜合征),這突顯了IDUA在人體健康中的重要作用。

熱銷產(chǎn)品

IDUA Antibody (CSB-PA011000LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA011000LA01HU

IHC image of CSB-PA011000LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA011000LA01HU

IHC image of CSB-PA011000LA01HU diluted at 1:300 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IDUA Antibodies

IDUA for Homo sapiens (Human)

IDUA Proteins

IDUA Proteins for Homo sapiens (Human)

IDUA ELISA Kit

IDUA ELISA Kit for Homo sapiens (Human)