IL12RB2
IL12RB2，全稱為白細胞介素12受體β2亞基，常被簡稱為IL-12Rβ2。它是免疫細胞表面的關鍵蛋白，需與另一個亞基配合才能讓細胞響應IL-12的作用，在免疫應答中扮演重要角色。這種蛋白能推動T細胞、自然殺傷細胞等免疫細胞的活化與分化，強化它們清除病原體和異常細胞的能力，是機體抗感染、抗腫瘤的重要助力。
IL12RB2功能異常，易打破免疫平衡：部分慢性感染患者因它表達不足，免疫應答難以有效清除病原體；而在多發性硬化癥等自身免疫病中，它可能過度激活免疫反應，導致自身組織受損。此外，一些腫瘤會通過降低該蛋白的表達躲避免疫系統攻擊。目前，針對這一蛋白相關通路的藥物研發正推進，部分靶向抑制劑進入臨床試驗，用于控制自身免疫病的過度炎癥；同時也有研究探索提升其功能以增強腫瘤免疫療法效果，為癌癥治療開辟新方向。
熱銷產品
Recombinant Human Interleukin-12 receptor subunit beta-2 (IL12RB2), partial (CSB-BP859518HUd7)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL12RB2 Antibody (CSB-PA859518LA01HU)
驗證數據
Immunofluorescence staining of HepG2 cells with CSB-PA859518LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IL12RB2 Antibodies
IL12RB2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA953263 | IL12RB2 Antibody | Human | ELISA,IHC |
| CSB-PA944056 | IL12RB2 Antibody | Human | ELISA,IHC |
| CSB-PA859518LA01HU | IL12RB2 Antibody | Human | ELISA, IF |
| CSB-PA859518LB01HU | IL12RB2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA859518LC01HU | IL12RB2 Antibody, FITC conjugated | Human | |
| CSB-PA859518LD01HU | IL12RB2 Antibody, Biotin conjugated | Human | ELISA |
IL12RB2 Proteins
IL12RB2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011589MO CSB-EP011589MO CSB-BP011589MO CSB-MP011589MO CSB-EP011589MO-B |
Recombinant Mouse Interleukin-12 receptor subunit beta-2 (Il12rb2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12RB2 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP847578PI CSB-EP847578PI CSB-BP847578PI CSB-MP847578PI CSB-EP847578PI-B |
Recombinant Pig Interleukin-12 receptor subunit beta-2 (IL12RB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12RB2 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP858989BO CSB-EP858989BO CSB-BP858989BO CSB-MP858989BO CSB-EP858989BO-B |
Recombinant Bovine Interleukin-12 receptor subunit beta-2 (IL12RB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12RB2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP859518HU | Recombinant Human Interleukin-12 receptor subunit beta-2 (IL12RB2), partial | Yeast |
| CSB-EP859518HU CSB-MP859518HU CSB-EP859518HU-B |
Recombinant Human Interleukin-12 receptor subunit beta-2 (IL12RB2), partial | E.coli Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP859518HU | Recombinant Human Interleukin-12 receptor subunit beta-2 (IL12RB2), partial | Baculovirus |
| CSB-BP859518HU1 | Recombinant Human Interleukin-12 receptor subunit beta-2 (IL12RB2), partial | Baculovirus |
| CSB-BP859518HUd7 | Recombinant Human Interleukin-12 receptor subunit beta-2 (IL12RB2), partial | Baculovirus |
