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IL23

IL-23(白細胞介素-23)是一種由IL-23p19和IL-12/IL-23p40兩個亞基組成的異源二聚體細胞因子,與IL-12共享p40亞基。IL-23主要通過與其受體IL-23受體相互作用來激活下游信號通路,發揮生物學功能。IL-23受體由IL-12受體β1(IL-12Rβ1)和IL-23受體兩個亞基組成,是一種跨膜蛋白。IL-23在機體的炎性免疫反應和IL-17的產生過程中發揮重要作用,主要作用于Th17細胞,促進其增殖與穩定,并誘導Th17細胞產生IL-17A、IL-17F、IL-22等細胞因子,參與多種疾病的發生發展。 IL-23參與的信號通路主要包括JAK/STAT、MAPK和PI3K等信號轉導途徑。當IL-23與其受體結合后,觸發IL-12Rβ1和IL-23R的異源二聚化,激活這些信號通路。IL-23通過RORγt和STAT3等轉錄因子發揮作用,促進Th17細胞的分化和效應子功能。此外,IL-23還與腫瘤免疫、自身免疫性疾病的發生發展有關,例如通過抑制細胞毒性T細胞在腫瘤組織中的浸潤促進腫瘤生長,IL-23R的遺傳變異體與多種腫瘤的發生有關,血清IL-23水平的升高與某些癌癥的發展階段相關。因此,IL-23在調節免疫反應、促進炎癥反應以及參與腫瘤免疫和自身免疫性疾病的發生發展中發揮著關鍵作用。

熱銷產品

IL12&IL23 monoclonal antibody (CSB-RA011587MA1HU)

驗證數據

CSB-RA011587MA1HU

The Binding Activity of IL12B&IL12A with Anti-IL12/IL23 monoclonal antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL12B&IL12A (CSB-MP4155HU) at 1 μg/mL can bind Anti-IL12/IL23 recombinant antibody, the EC50 is 1.042-1.545 ng/mL.

CSB-RA011587MA1HU

IHC image of CSB-RA011587MA1HU diluted at 1:50 and staining in paraffin-embedded human lymphnode tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

IL23 Antibodies

IL23 for Homo sapiens (Human)

IL23 Proteins

IL23 Proteins for Homo sapiens (Human)

IL23 ELISA Kit

IL23 ELISA Kit for Homo sapiens (Human)