IL23A

IL23A，即白細(xì)胞介素23α，是位于12號(hào)染色體上的一個(gè)基因。該基因編碼的蛋白質(zhì)是白細(xì)胞介素23（IL-23）的一個(gè)亞單位，與IL12B基因編碼的p40亞基結(jié)合，形成具有生物學(xué)活性的IL-23異二聚體。IL-23通過與其特異性受體IL23R結(jié)合，激活下游信號(hào)傳導(dǎo)，主要通過JAK-STAT途徑，特別是STAT3和STAT4的激活，促進(jìn)Th17細(xì)胞的分化和增殖，以及細(xì)胞因子如IL-17和IL-22的產(chǎn)生。IL23A在調(diào)節(jié)免疫反應(yīng)中起著關(guān)鍵作用，特別是在促進(jìn)Th17細(xì)胞介導(dǎo)的免疫反應(yīng)中。Th17細(xì)胞與多種炎癥性和自身免疫性疾病的發(fā)生發(fā)展密切相關(guān)，如炎癥性腸病、銀屑病和多發(fā)性硬化癥等。此外，IL-23在腫瘤免疫中也發(fā)揮作用，影響腫瘤的生長(zhǎng)和免疫抑制環(huán)境。因此，IL23A是免疫調(diào)節(jié)和相關(guān)疾病治療研究中的一個(gè)重要分子。

熱銷產(chǎn)品

Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A) (CSB-EP757211GU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IL23A Recombinant Monoclonal Antibody (CSB-RA251959A0HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: THP-1 whole cell lysate
All lanes: IL23 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 21 kDa
Observed band size: 21 kDa

Human Interleukin-23 subunit alpha(IL-23A) Elisa kit (CSB-E17339h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E17339h

規(guī)格：96T/48T

靈敏度：15.6 pg/mL

檢測(cè)范圍：62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

IL23A Antibody

IL23A Protein

IL23A ELISA Kit

IL23A Antibodies

IL23A for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA06719A0Rb	IL23A Antibody	Human	ELISA, IHC, IF
CSB-PA06719B0Rb	IL23A Antibody, HRP conjugated	Human	ELISA
CSB-PA06719C0Rb	IL23A Antibody, FITC conjugated	Human
CSB-PA06719D0Rb	IL23A Antibody, Biotin conjugated	Human	ELISA
CSB-RA251959A0HU	IL23A Recombinant Monoclonal Antibody	Human	ELISA, WB

IL23A Proteins

IL23A Proteins for Equus caballus (Horse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP727376HO CSB-EP727376HO CSB-BP727376HO CSB-MP727376HO CSB-EP727376HO-B	Recombinant Horse Interleukin-23 subunit alpha (IL23A)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL23A Proteins for Cavia porcellus (Guinea pig)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP757211GU CSB-BP757211GU CSB-MP757211GU CSB-EP757211GU-B	Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP757211GU	Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A)	E.coli

IL23A Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP852813RA CSB-EP852813RA CSB-BP852813RA CSB-MP852813RA CSB-EP852813RA-B	Recombinant Rat Interleukin-23 subunit alpha (Il23a)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL23A Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP863641MO CSB-BP863641MO CSB-EP863641MO-B	Recombinant Mouse Interleukin-23 subunit alpha (Il23a)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP863641MO	Recombinant Mouse Interleukin-23 subunit alpha (Il23a)	E.coli
CSB-CF863641MOd7	Recombinant Mouse Interleukin-23 subunit alpha (Il23a)	in vitro E.coli expression system

IL23A Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP868278HU CSB-EP868278HU CSB-BP868278HU	Recombinant Human Interleukin-23 subunit alpha (IL23A)	Yeast E.coli Baculovirus
CSB-AP004661HU	Recombinant Human IL23A & IL12B Heterodimer Protein (Active)	Mammalian cell

IL23A Proteins for Sus scrofa (Pig)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP873568PI CSB-BP873568PI CSB-EP873568PI-B	Recombinant Pig Interleukin-23 subunit alpha (IL23A)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-CF873568PI	Recombinant Pig Interleukin-23 subunit alpha (IL23A)	in vitro E.coli expression system