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ITGAX

ITGAX,全稱為整合素αX鏈蛋白,常見別名包括CD11c和補(bǔ)體成分3受體4亞基。該蛋白是白細(xì)胞特異性整合素的重要組成部分,與β2鏈(ITGB2)結(jié)合形成復(fù)合物,參與細(xì)胞粘附、遷移和信號(hào)傳導(dǎo)等過程。ITGAX蛋白在免疫細(xì)胞中發(fā)揮關(guān)鍵作用,尤其是在樹突狀細(xì)胞、單核細(xì)胞和巨噬細(xì)胞中高表達(dá)。它參與多種免疫反應(yīng),包括炎癥反應(yīng)、抗原呈遞和免疫調(diào)節(jié)。ITGAX蛋白還與某些疾病的發(fā)生發(fā)展密切相關(guān),如癌癥、自身免疫性疾病和感染性疾病。在藥物研發(fā)方面,針對(duì)ITGAX蛋白的抗體藥物和抑制劑已被開發(fā)用于治療癌癥和炎癥性疾病。例如,抗ITGAX抗體可用于阻斷腫瘤細(xì)胞的粘附和轉(zhuǎn)移,而ITGAX抑制劑則可減輕炎癥反應(yīng)。目前,ITGAX蛋白相關(guān)的研究仍在不斷深入,未來有望為更多疾病的治療提供新的策略。

熱銷產(chǎn)品

ITGAX Antibody (CSB-PA782639)

驗(yàn)證數(shù)據(jù)

CSB-PA782639

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA782639(ITGAX Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA782639

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA782639(ITGAX Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)

ITGAX Antibody (CSB-PA011879ESR1HU)

驗(yàn)證數(shù)據(jù)

CSB-PA011879ESR1HU

Western blot
All lanes: ITGAXantibody IgG at 1.59μg/ml + Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 128 kDa
Observed band size: 128 kDa

CSB-PA011879ESR1HU

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA011879ESR1HU at dilution of 1:100

CSB-PA011879ESR1HU

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA011879ESR1HU at dilution of 1:100

CSB-PA011879ESR1HU

Immunofluorescent analysis of Hela cells using CSB-PA011879ESR1HU at dilution of 1: 100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

ITGAX Antibodies

ITGAX for Homo sapiens (Human)

ITGAX Proteins

ITGAX Proteins for Homo sapiens (Human)

ITGAX Proteins for Mus musculus (Mouse)



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