JAG1
JAG1，即Jagged1蛋白，別名AGS、AHD、AWS、HJ1、AGS1、DCHE、CD339、JAGL1、CMT2HH。
JAG1在成人和胎兒組織中廣泛表達(dá)，其表達(dá)在宮頸鱗狀細(xì)胞癌中上調(diào)，并在骨髓細(xì)胞系HS-27a中表達(dá)。
JAG1是多個(gè)Notch受體的配體，參與調(diào)節(jié)Notch信號(hào)傳導(dǎo)。JAG1在哺乳動(dòng)物心血管發(fā)育的早期和晚期階段都有所涉及，它通過抑制成肌細(xì)胞分化和增強(qiáng)成纖維細(xì)胞生長因子誘導(dǎo)的血管生成來發(fā)揮作用。
JAG1與多種疾病相關(guān)，包括Alagille綜合征和某些類型的癌癥，如乳腺癌和腎上腺皮質(zhì)癌。JAG1的突變與Alagille綜合征相關(guān)，這是一種主要影響肝臟、心臟、骨骼、眼睛、面部、腎臟和血管系統(tǒng)的多系統(tǒng)顯性障礙，表明JAG1的功能喪失是導(dǎo)致這些組織疾病的原因。
熱銷產(chǎn)品
Recombinant Human Protein jagged-1 (JAG1), partial (CSB-MP011927HUh6)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
JAG1 Antibody (CSB-PA01949A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA01949A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA01949A0Rb at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA01949A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Protein jagged-1(JAG1) ELISA kit (CSB-EL011927HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL011927HU
規(guī)格：96T/48T
靈敏度：0.039 ng/mL
檢測(cè)范圍：0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
JAG1 Antibodies
JAG1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005638 | JAG1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA969766 | JAG1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA234352 | JAG1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA01949A0Rb | JAG1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA01949B0Rb | JAG1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA01949C0Rb | JAG1 Antibody, FITC conjugated | Human | |
| CSB-PA01949D0Rb | JAG1 Antibody, Biotin conjugated | Human | ELISA |
JAG1 Proteins
JAG1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011927HU CSB-EP011927HU CSB-BP011927HU CSB-MP011927HU CSB-EP011927HU-B |
Recombinant Human Protein jagged-1 (JAG1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP011927HUh6 | Recombinant Human Protein jagged-1 (JAG1), partial | Mammalian cell |
JAG1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP730923RA CSB-EP730923RA CSB-BP730923RA CSB-MP730923RA CSB-EP730923RA-B |
Recombinant Rat Protein jagged-1 (Jag1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAG1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP870758MO CSB-BP870758MO CSB-MP870758MO CSB-EP870758MO-B |
Recombinant Mouse Protein jagged-1 (Jag1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP870758MO | Recombinant Mouse Protein jagged-1 (Jag1), partial | E.coli |
JAG1 ELISA Kit
JAG1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011927HU | Human Protein jagged-1(JAG1) ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
